Obstructive Sleep Apnea and Risk of Motor Vehicle Crash: Systematic Review and Meta-Analysis
2009; American Academy of Sleep Medicine; Volume: 05; Issue: 06 Linguagem: Inglês
10.5664/jcsm.27662
ISSN1550-9397
AutoresStephen Tregear, James Reston, Karen M Schoelles, Barbara Phillips,
Tópico(s)Cardiovascular and Diving-Related Complications
ResumoFree AccessCPAPObstructive Sleep Apnea and Risk of Motor Vehicle Crash: Systematic Review and Meta-Analysis Stephen Tregear, Ph.D., James Reston, Ph.D., M.P.H., Karen Schoelles, M.D., S.M., Barbara Phillips, M.D., M.S.P.H. Stephen Tregear, Ph.D. MANILA Consulting Group, McLean, VA , James Reston, Ph.D., M.P.H. ECRI Institute, Plymouth Meeting, PA , Karen Schoelles, M.D., S.M. ECRI Institute, Plymouth Meeting, PA , Barbara Phillips, M.D., M.S.P.H. Address correspondence to: Barbara Phillips, MD, MSPH, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, 5th Floor KY Clinic, University of KY College of Medicine, 800 Rose St, Lexington, KY, 40536-0298(859) 269-8340(859) 226-7008 E-mail Address: [email protected] Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY Published Online:December 15, 2009https://doi.org/10.5664/jcsm.27662Cited by:371SectionsAbstractPDF ShareShare onFacebookTwitterLinkedInRedditEmail ToolsAdd to favoritesDownload CitationsTrack Citations AboutABSTRACTStudy Objectives:We performed a systematic review of the OSA-related risk of crash in commercial motor vehicle (CMV) drivers. The primary objective involved determining whether individuals with obstructive sleep apnea (OSA) are at an increased risk for a motor vehicle crash when compared to comparable individuals who do not have the disorder. A secondary objective involved determining what factors are associated with an increased motor vehicle crash risk among individuals with OSA.Design/Setting:Seven electronic databases (MEDLINE, PubMed (PreMEDLINE), EMBASE, PsycINFO, CINAHL, TRIS, and the Cochrane library) were searched (through May 27, 2009), as well as the reference lists of all obtained articles. We included controlled studies (case-control or cohort) that evaluated crash risk in individuals with OSA. We evaluated the quality of each study and the interplay between the quality, quantity, robustness, and consistency of the body of evidence, and tested for publication bias. Data were extracted by 2 independent analysts. When appropriate, data from different studies were combined in a fixed- or random-effects meta-analysis.Results:Individuals with OSA are clearly at increased risk for crash. The mean crash-rate ratio associated with OSA is likely to fall within the range of 1.21 to 4.89. Characteristics that may predict crash in drivers with OSA include BMI, apnea plus hypopnea index, oxygen saturation, and possibly daytime sleepiness.Conclusions:Untreated sleep apnea is a significant contributor to motor vehicle crashes.Citation:Tregear S; Reston J; Schoelles K; Phillips B. Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis. J Clin Sleep Med 2009;5(6):573-581.INTRODUCTIONOf all occupations in the United States, workers in the trucking industry experience the third highest fatality rate, accounting for 12% of all worker deaths. In 2006, there were 368,000 police-reported large truck crashes, resulting in 4,321 fatalities and 77,000 injuries.1 The Federal Motor Carrier Safety Administration (FMCSA) was established as a separate administration within the U.S. Department of Transportation (DOT) pursuant to the Motor Carrier Safety Improvement Act of 1999. The primary mission of the FMCSA is to reduce crashes, injuries and fatalities involving large trucks and buses. Among the strategies employed by the FMCSA to accomplish this goal are the development and maintenance of medical fitness standards for drivers of commercial vehicles; these standards are applied by medical examiners to commercial drivers, who are required by Federal statute to undergo medical qualification examinations at least every 2 years.Obstructive sleep apnea (OSA) is a prevalent and potentially dangerous condition among commercial motor vehicle (CMV) drivers. While OSA is conservatively estimated to affect approximately 5% of the general population,2 the condition appears to be much more prevalent in commercial drivers. Howard et al. estimated that 50% of more than 3000 commercial drivers were at risk for sleep apnea.3 Pack et al. found that 28.2% of 406 commercial drivers had at least mild sleep apnea and 4.7% had severe sleep apnea by conventional criteria.4 The majority of research indicates that OSA is a significant cause of motor vehicle crashes.3,5–9 Thus, assessment of the risk of OSA and development of effective methods to identify and treat commercial drivers with OSA is an important part of the mission of the FMCSA. Since the most recent standards for medical examiners regarding OSA are from a Federal Highway Administration (FHWA) sponsored conference in 1991,10 these standards required an evidence-based update.The current study was designed to provide evidence for updating the standards by conducting a systematic review of the relevant literature concerning OSA and CMV drivers. The literature consists predominantly of cohort and case-control studies. Given that few studies specifically enroll CMV drivers, studies that included non-CMV drivers were also evaluated.The primary objective of this study was to determine whether individuals with OSA are at an increased risk for a motor vehicle crash when compared to individuals without OSA. If so, a secondary objective was to identify disease-related factors associated with an increased motor vehicle crash risk.METHODSIdentification of Evidence BasesSeparate evidence bases for each of the objectives of this evidence report were identified using a process consisting of a comprehensive search of the literature; examination of abstracts of identified studies to determine which articles would be retrieved; and the selection of the actual articles that would be included in each evidence base.A total of 7 electronic databases (MEDLINE, PubMed (PreMEDLINE), EMBASE, PsycINFO, CINAHL, TRIS, and the Cochrane library) were searched (through May 27, 2009). All database searches were conducted by masters-level medical librarians. To supplement the electronic searches, we also examined the bibliographies/reference lists of included studies, recent narrative reviews, and scanned the content of new issues of selected journals and selected relevant gray literature sources. A complete list of the electronic databases searched and the search strategy used to identify relevant studies are available upon request. Admission of an article into an evidence base was determined by the inclusion criteria listed in Table 1.Table 1 Inclusion CriteriaInclusion Criteria (General) Article must have been published in the English language. Article must be a full-length article (no abstracts or letters to the editor). Article must have enrolled 10 or more subjects. Article must have enrolled subjects aged ≥18 y. If the same study is reported in multiple publications, the most complete publication will be the primary reference. Data will be extracted to avoid double-counting individuals. Studies were limited to individuals with OSA only (no central apneas). Studies that evaluated both OSA and other sleep disordered individuals were included as long as data for OSA subjects could be analyzed separately from that of other subject populations.Inclusion Criteria (Primary Objective) Article must describe a study that attempted to directly determine the risk for a motor vehicle crash (risk for a fatal or nonfatal crash) associated with OSA using a direct measure of crash (no indirect measures; e.g., driving simulator data). Article must describe a study that includes a comparison group comprised of comparable subjects who do not have OSA. Article must present motor vehicle crash-risk data in a manner that allows ECRI Institute to calculate (directly or through imputation) effect-size estimates and confidence intervals.Inclusion Criteria (Secondary Objective) Article must describe a study that attempted to determine the disease-related factors associated with an increased risk for a motor vehicle crash (risk for a fatal or nonfatal crash) among individuals with OSA. Article must describe a study that includes a comparison group comprised of comparable subjects with OSA who did not have a motor vehicle crash. Article must present motor vehicle crash-risk data in a manner that will allow ECRI Institute to calculate (directly or through imputation) effect-size estimates and confidence intervals.Analytic MethodsData were extracted by 2 independent analysts. Individual study quality was assessed using quality scales modified from the Newcastle-Ottawa quality instruments for cohort and case-control studies.11 For uncontrolled case series we used a separate instrument developed at ECRI Institute. These quality instruments are available upon request.Random- and fixed-effects meta-analyses were used to pool data from different studies.12–16 Differences in the findings of studies (heterogeneity) were identified using the Q-statistic and I2.17–19 Heterogeneity was explored with meta-regression of potential explanatory variables (study quality, clinic versus general population study) in Stata 10. Sensitivity analyses aimed at testing the robustness of findings included the use of cumulative fixed- and random-effects meta-analysis.20–22 The presence of publication bias was tested for using the "trim and fill"method.23–25RESULTSOSA and Crash RiskEighteen articles describing 18 unique studies met the inclusion criteria for the primary objective.3,5,7,8,9,26–38 Study characteristics are presented in Supplemental Table 1 (available online at www.aasmnet.org/JCSM). Only 2 of these studies enrolled distinct populations of CMV drivers.3,26 The remainder of the studies included private motor vehicle license holders, an unknown number of whom may have held commercial driver licenses. The studies used either a cohort design or a case-control design. The most commonly used methodology (16 studies) was to select a cohort of drivers with OSA and compare the incidence of crash over a defined time period with the incidence of crash occurring over a similar time period among comparable individuals without the condition. The less commonly used approach (2 studies) was to compare the prevalence of OSA among individuals who experienced a crash (cases) and those who did not (controls).A design problem common in many risk-assessment studies is the failure to control adequately for exposure. In this instance, the exposure variables of critical importance are the number of miles driven per unit time and the time frame over which data were collected. If cohorts or cases and controls are not well-matched for exposure to risk, then any observed differences in the risk may simply be the consequence of differences in exposure. A majority of the included studies attempted to control for both of these exposure variables.Crash rates were determined from data obtained from 2 primary sources: databases and questionnaires. The degree of confidence that one can have in crash rates derived from questionnaires is unclear, primarily because questionnaires depend on reliable reporting by the individual being questioned.Studies of CMV DriversTwo studies included only CMV drivers. Howard et al. compared crash risk among drivers with OSA (symptom diagnosis) and drivers not diagnosed with OSA (controls).3 They measured the prevalence of excessive sleepiness and sleep-disordered breathing, and assessed crash-risk factors in 2,342 respondents to a questionnaire distributed to a random sample of 3,268 Australian commercial vehicle drivers and another 161 drivers among 244 invited to undergo formal sleep studies. Howard et al. presented the odds ratio (OR) for having a crash in the past 3 years in drivers with OSA adjusted for age, hours of driving, and alcohol intake. Drivers diagnosed with OSA based on a Multivariable Apnea Prediction Score (MAPS)39 ≥ 0.5 and Epworth Sleepiness Scale (ESS)40 score ≥ 11 were found to be at an increased risk for motor vehicle crash (OR = 1.3, 95% 1.00-1.69). The value of the findings of this study is weakened by the fact that individuals were diagnosed with sleep apnea using questionnaires only. The accuracy of this diagnosis was not confirmed via sleep lab investigations. Because diagnosis based on these questionnaires is subjective, it is unclear whether all individuals had received a correct diagnosis. This, combined with the retrospective outcome measurement and the reliance on self-reported crash data, resulted in this study being judged as low quality.Stoohs et al. assessed a possible independent effect of OSA on traffic crashes in long-haul commercial truck drivers.26 The study design included integrated analysis of recordings of sleep-related breathing disorders, and self-reported and company-recorded automotive crashes. A cross-sectional population of 90 commercial long-haul truck drivers 20 to 64 years of age was studied. Main outcome measures included presence or absence, as well as severity, of sleep-disordered breathing and frequency of automotive crashes. A "crash" was defined as the collision of the index case's vehicle with a stationary or moving object or as driving off the road in the absence of an obstacle.The study was performed at the main hub of a long-haul trucking company.26 Two hundred thirteen drivers were scheduled to spend the night at the facilities. Of these, 193 (92%) agreed to undergo monitoring during sleep: 34 had to terminate the monitoring prematurely and their data had to be discarded. Subjects who agreed to be monitored were tested overnight with an ambulatory screening device, the Mesam IV, a microprocessor that continuously monitors 4 variables throughout the night: heart rate, snoring sounds, oxygen saturation (SpO2), and body position/movement. These investigators performed 159 recordings of appropriate duration for analysis. Since some drivers were students with little professional driving experience, the authors decided only to include drivers with a driving history ≥ 2 months. Overnight recordings, completed questionnaires, and crash records were analyzed for 90 truck drivers. Analyses of overnight recordings were used to identify obstructive hypopnea and apnea. The sleep logs were used to calculate total sleep time (TST) and oxygen desaturation index (ODI).For analysis, Stoohs et al. considered the total number of vehicle crashes.26 They obtained information on mileage both from the trucking company and from the drivers' self-reported usage of private vehicles. All crash rates were adjusted for annual mileage of individual truck drivers. These investigators found that truck drivers identified with sleep disordered breathing (SDB) had a 2-fold higher crash rate per mile than drivers without SDB. Crash frequency was not dependent on the severity of the sleep related breathing disorder. Obese drivers with a body mass index (BMI) ≥ 30 kg/m2 also presented a 2-fold higher crash rate than non-obese drivers. In addition, the authors found that a complaint of EDS was related to a significantly higher automotive crash rate in long-haul commercial truck drivers. SDB with hypoxemia and obesity are risk factors for automotive crashes. This study was assessed as moderate quality because the majority of crash data came from company records rather than self-report.Studies of All DriversOf the 18 included studies, 16 studies reported on the incidence of crashes occurring among populations of individuals with OSA and the incidence of crashes occurring among individuals without the disorder.2,3,5,7,9,26–28,30–34,36–38 These studies were mostly rated as low quality due to retrospective design, lack of adjustment for important potential confounders, and self-reported outcome or lack of independent outcome assessment. Ten of these studies provided enough data to determine the crash relative risk (RR) and 95% confidence intervals (CIs) for individuals who have OSA versus comparable individuals without the disorder.5,7,26–28,31–33,36,38 A test of homogeneity found that the findings of the 10 studies were heterogeneous (Q = 83.9, P < 0.001; I2 = 89%). Exploration of this heterogeneity using meta-regression techniques found that neither study quality nor derivation of study groups (clinic versus general population) explained the heterogeneity. Therefore, we pooled these data using a random-effects meta-analysis (Figure 1). The findings of this meta-analysis provide support for the contention that drivers with OSA are at a significantly increased risk for experiencing a motor vehicle crash when compared to comparable individuals without OSA (crash RR = 2.43, 95% CI: 1.21-4.89: p = 0.013). In other words, if one assumes that the underlying crash risk for a driver is 0.08 crashes per person-year, the crash risk for a driver with OSA can be estimated to be 0.19 (95% CI: 0.10 to 0.39) crashes per person-year. A series of sensitivity analyses (removal of one study at a time, cumulative meta-analysis by publication date) demonstrated our finding that individuals with OSA are at an increased risk for a motor vehicle crash to be robust. The "trim and fill" test did not detect publication bias.Figure 1 Crash Risk among Individuals with OSA Compared to Controls (Random-effects Meta analysis)Download FigureTwo of the 18 studies presented data on the odds of an individual who experienced a crash having OSA relative to the odds of a comparable individual who did not crash having OSA.8,29 One study was rated as low quality for reasons described above; the remaining study was rated as moderate quality because crash data was obtained from secure records. The findings of these studies are summarized in Figure 2. One of the 2 studies8 suggested that OSA increased crash risk, and the other29 found no evidence of an increase or a decrease in crash risk.Figure 2 OSA and Crash Risk (OR)Download FigureDisease-Related Factors and Crash RiskOur assessment of the evidence pertaining to crash risk found that drivers with OSA (both commercial and noncommercial) are at a significantly increased risk for a motor vehicle crash when compared with comparable drivers who do not have the disorder. Not all individuals with OSA, however, appear to be at increased risk. A secondary objective was to determine whether there are specific risk factors that are predictive of which individuals with OSA are at the greatest risk for a crash. The identification of such risk factors is important, because it will enable medical examiners to differentiate high-risk individuals from low-risk individuals when making decisions about fitness-to-drive certification.Thirteen articles describing 13 unique studies met the inclusion criteria for this objective, and are summarized in Supplemental Table 2 (available online at www.aasmnet.org/JCSM).5,9,26,27,33,37,41–46 Three of these studies were graded as being of moderate quality, while the remaining 10 studies were graded as being of low quality due to retrospective design, lack of adjustment for important potential confounders, and self-reported outcome or lack of independent outcome assessment. One of the studies assessed the factors predictive of crash among CMV drivers with OSA. All of these studies examined several factors caused by OSA that are thought to be associated with an increase in an individual's risk for a motor vehicle crash (Supplemental Tables 2 and 3, available online at www.aasmnet.org/JCSM). These factors—all of which serve as surrogate indicators of disease severity—included the presence and degree of daytime sleepiness,7,9,27,37,42–46 the severity of disordered respiration during sleep,5,7,26,27,33,37,42–46 and nighttime oxygen saturation (SpO2).37,43–46 In addition to these three factors, some included studies also examined the relationship between BMI and the risk of a motor vehicle crash.7,26,27,43 Since a high BMI is a risk factor for OSA, it may also be considered to be a surrogate marker for OSA severity because it is strongly correlated with the severity of the disorder.47–50 In addition, 3 studies examined the relationship between cognitive and psychomotor functioning and the risk of a motor vehicle crash.41,42,44SleepinessEight included studies reported on the relationship between sleepiness and crash risk among populations of individuals with OSA,7,27,37,42–45 and 3 of these 8 studies (rated as low quality for reasons mentioned above) provided data sufficient to calculate effect-size estimates (and 95% confidence intervals) which could be pooled using meta-analysis.7,43,45 All 3 measured daytime sleepiness subjectively using the ESS.40 A test of homogeneity found that the findings from these 3 studies for which an effect-size estimate could be calculated were heterogeneous (Q = 6.46, p = 0.040; I2 = 69.05%). Consequently, we pooled the data from the three studies using a random-effects meta-analysis. The result suggested a trend toward an increased crash risk in individuals with higher ESS scores, but the finding was not quite statistically significant (SMD = 0.64, 95% CI: −0.03 to 1.30; P = 0.061). Also, these 3 studies did not adjust for the effect of other factors (such as age, gender, and alcohol use). Likewise, 4 additional studies could not confirm an increased crash risk based on higher ESS scores,9,27,42,44 (although one of these studies found a significantly higher risk of near-miss accidents among drivers with higher ESS scores). However, daytime sleepiness from any cause has been associated with increased crash risk.51–53Two studies used the multiple sleep latency test (MSLT)54 to objectively measure sleepiness. In one report Aldrich found that there were no significant differences in mean sleep latency between individuals with crashes and those without (males, 8.2 min vs. 7.8 min; females, 7.3 min vs. 7.6 min).37 Young et al. also found no significant differences on the MSLT, although there was a trend toward lower scores (indicating greater sleepiness) among men with more than one crash (4.5 ± 2.7) compared to men who did not crash (8.8 ± 0.3).9Disease SeverityEleven included studies reported on the relationship between disease severity and crash risk among populations of individuals with OSA.5,7,26,27,33,37,42–46 Three of these 11 studies (judged to be of low quality for reasons mentioned above) provided data sufficient to calculate an effect-size estimate.7,43,46 All 3 employed the apnea plus hypopnea index (AHI) to quantify the severity of disordered respiration during sleep. A test of homogeneity found that the findings of the 3 studies for which an effect-size estimate could be calculated did not differ substantially (Q = 1.6, p = 0.45; I2 = 0.0%). Consequently, we pooled the data from the 3 studies using a fixed-effects meta-analysis. The results suggested a trend toward greater severity of disordered respiration during sleep (measured using the AHI) among individuals with OSA who crashed, but again the findings did not quite reach statistical significance (SMD = 0.27, 95% CI: −0.006 to 0.54; p = 0.055). The findings of the 8 studies not included in the meta-analysis were mixed. Three studies found that severity of disordered breathing during sleep was associated with an increased risk for a motor vehicle crash.5,33,37 The remaining 5 studies found that severity of disordered breathing during sleep was not associated with an increased risk for a motor vehicle crash.26,27,42,43,45 Though the findings suggest the possibility that the severity of disordered breathing may be related to crash risk, a definitive conclusion cannot be drawn at this time.Oxygen SaturationFive included studies reported on the relationship between a measure of SpO2 and crash risk among populations of individuals with OSA.37,43–46 Data from these 5 studies (rated as low quality for reasons mentioned earlier) were reported using several different methods, and as a result we were precluded from pooling their findings in a meta-analysis. Two studies found that total oxygen desaturation time (time during which oxygen saturation was decreased < 90%)45 or nocturnal hypoxemia46 correlated with crash score45 or sleep-related near-miss crashes.46 One study determined that there was no statistical difference between individuals who experienced a crash and individuals who did not experience a crash with regards to mean SpO2 and lowest SpO2.43 However, the data did indicate that individuals who experienced a crash were more likely to have lower SpO2 levels. A separate study found that males who experienced a crash had a significantly lower minimum SpO2 compared to males who did not experience a crash.37 Finally, one study found that neither mean SpO2 nor time below 90% SpO2 was related to number of crashes.44 Taking all of this information into account, it appears that hypoxemia may be a risk factor for a motor vehicle crash in individuals with OSA, but the level at which this occurs, and how best to measure it are unclear from these studies.Body Mass Index (BMI)Four included studies reported on the relationship between BMI and crash risk among populations of individuals with OSA.7,26,27,43 Differences in measures of effect precluded us from pooling their findings in a meta-analysis. Stoohs et al. examined the relationship between BMI and automobile crashes in 90 commercial long-haul truck drivers (moderate quality study).26 Individuals were classified into 4 categories: BMI < 25 kg/m2, BMI ≥ 25 < 28 kg/m2, BMI ≥ 28 < 30 kg/m2, and BMI ≥ 32 kg/m2. Drivers whose BMI exceeded ≥ 30 kg/m2 were classified as obese. The authors found that automobile crash rate increased with increasing BMI: 0.031 crashes/10,000 miles (BMI < 25 kg/m2); 0.041 crashes/10,000 miles (BMI ≥ 25 < 28 kg/m2); 0.079 crashes/10,000 miles (BMI ≥ 28 < 30 kg/m2); and 0.101 crashes/10,000 miles (BMI ≥ 32 kg/m2) (p < 0.05). In addition, Stoohs et al. reported that non-obese drivers had a mean of 0.045 crashes/10,000 miles within the last 5 years compared to a mean of 0.1 crashes/10,000 miles (p < 0.03) within the last 5 years in obese truck drivers. Using the scores for obesity ( ≥ 30 kg/m2) as a predictor for crashes, they found that this predictor had a sensitivity of 49% and a specificity of 71%. Horstmann et al. examined the relationship between BMI and automobile crashes in 130 individuals who were diagnosed as having sleep apnea syndrome (SAS).7 Individuals were categorized on the basis of whether or not they had experienced a crash during the previous 3 years. Mean BMI was then compared between the 2 groups. The authors found that individuals who experienced a crash during the previous 3 years had a mean BMI of 35.1 kg/m2, whereas individuals who did not experience a crash had a mean BMI of 30.9 kg/m2 (p = 0.02). Yamamoto et al. examined the relationship between BMI and automobile crashes in 39 individuals who were diagnosed with OSA.43 Individuals were categorized on the basis of whether or not they had experienced a crash during the previous 2 years. Mean BMI was then compared between the 2 groups. The authors found that individuals who experienced a crash during the previous two years had a mean BMI of 32.4 kg/m2, whereas individuals who did not experience a crash had a mean BMI of 28.0 kg/m2 (p < 0.05). Mulgrew et al. found a small but statistically significant association between higher BMI and crash risk in a multivariable model (rate ratio 1.01, 95% CI: 1.00 to 1.02, p = 0.008).27 In summary, all 4 studies reporting on BMI and crash risk found that higher BMI is a risk factor for a motor vehicle crash in individuals with OSA.Cognition and Psychomotor FunctionThree included studies reported on the relationship between cognitive/psychomotor function and crash risk among populations of individuals with OSA.41,42,44 The low quality of these studies and differences in measures of effect precluded us from pooling their findings in a meta-analysis. Turkington et al.. performed a multivariable analysis and found a relationship between the number of simulated off-road events and crashes in the previous year (OR 1.004, 95% CI 1.0004–1.008, p < 0.03), but the effect size is very small.42 In contrast, a multivariable analysis by Barbe et al. found that mean reaction time, reaction fatigue, and percentage of simulated crashes on a driving simulator were not related to the number of crashes in drivers with SAS.44 Although Pizza et al. reported that a history of car crashes was associated with poor simulated driving performance, they did not adjust for other factors in their analysis.41In summary, 4 factors may be associated with crash risk among the general driver population with OSA. These factors include BMI, severity of disordered respiration during sleep (as measured by the AHI), and hypoxemia. The presence and degree of daytime sleepiness also may be associated with crash risk, but the available instruments for measurement of daytime sleepiness (ESS and MSLT) appear to insufficiently distinguish crash risk within the group of drivers with OSA.DISCUSSIONThe primary findings of this study of OSA and crash risk are that individuals with OSA are clearly at increased risk for crash. The findings are somewhat stronger for private than for commercial drivers because so few studies specifically enrolled commercial drivers. The mean crash-rate ratio associated with OSA is likely to fall within the range of 1.21 to 4.89 (95% CI of random-effects summary effect-size estimate). Thus, if the underlying crash risk for a driver is 0.08 crashes per person-year, the crash risk for a driver with OSA can be expected to be in the range of 0.10 to 0.39 crashes per person-year. Our analysis indicates that the characteristics which may predict crash in drivers with OSA include AHI, hypoxemia, BMI, and possibly daytime sleepiness.This report confirms and expands the systematic review of Ellen.55 In addition to confirming that drivers with OSA
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