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ELEVATION OF PROSTATE SPECIFIC ANTIGEN IN CARDIAC SURGERY WITH EXTRACORPOREAL CARDIOPULMONARY CIRCULATION

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(01)63759-5

1527-3792

Nelson Rodrígues Netto, Marcelo Lopes de Lima, MARCOS A. GUEDES, LUIS LARCO PATINO, João Bosco Oliveira,

Prostate Cancer Treatment and Research

No AccessJournal of UrologyClinical Urology: Original Articles1 Mar 1998ELEVATION OF PROSTATE SPECIFIC ANTIGEN IN CARDIAC SURGERY WITH EXTRACORPOREAL CARDIOPULMONARY CIRCULATION NELSON RODRIGUES NETTO, MARCELO LOPES LIMA, MARCOS A. GUEDES, LUIS LARCO PATINO, and JOAO BOSCO de OLIVEIRA NELSON RODRIGUES NETTONELSON RODRIGUES NETTO , MARCELO LOPES LIMAMARCELO LOPES LIMA , MARCOS A. GUEDESMARCOS A. GUEDES , LUIS LARCO PATINOLUIS LARCO PATINO , and JOAO BOSCO de OLIVEIRAJOAO BOSCO de OLIVEIRA View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63759-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We evaluated the correlation of prostate specific antigen (PSA) and cardiac surgery in a group of patients with symptomatic benign prostatic hyperplasia operated on with or without extracorporeal cardiopulmonary circulation. Materials and Methods: A total of 30 men 54 to 72 years old (mean age 62 years) undergoing cardiac surgery had PSA measured preoperatively and postoperatively. To provide the baseline PSA value a first serum sample was obtained before surgery, and PSA measurements were repeated 12 hours and 7 days postoperatively. Cardiac surgery was performed with extracorporeal cardiopulmonary circulation in 20 cases and without cardiopulmonary bypass in 10, constituted the control group. An 18F Foley catheter was left indwelling for the first 24 hours in both groups. Results: In the study group there was a significant increase in PSA postoperatively (p = 0.01). However, in the control group the PSA was not statistically different before or after surgery (p = 0.16). These results indicate that there was a physiological relationship between the extracorporeal cardiopulmonary circulation and PSA. Conclusions: Although the etiology of this elevation is unknown, based on our data we conclude that extracorporeal cardiopulmonary circulation can cause an alteration in serum PSA unrelated to cardiac operation without extracorporeal bypass. References 1 : Effect of digital rectal examination and needle biopsy on serum total and percentage of free prostate-specific antigen levels. J. Urol.1997; 157: 195. Abstract, Google Scholar 2 : Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med.1987; 317: 909. Crossref, Medline, Google Scholar 3 : Effect of cystoscopy, prostate biopsy, and transurethral resection of prostate on serum prostate-specific antigen concentration. Urology1993; 42: 276. Google Scholar 4 : Effects of rectal examination, prostatic massage, ultrasonography and needle biopsy on serum specific antigen levels. J. Urol.1992; 147: 810. Abstract, Google Scholar 5 : Nontraumatic elevation of prostate specific antigen following cardiac surgery and extracorporeal cardiopulmonary bypass. J. Urol.1994; 152: 2043. Link, Google Scholar 6 : Prostate specific antigen and prostatic acid phosphatase in the monitoring and staging of patients with prostatic cancer. J. Urol.1987; 138: 1181. Link, Google Scholar 7 : Tumour markers in prostatic carcinoma. A comparison of prostatic-specific antigen with acid phosphatase. Brit. J. Urol.1987; 60: 69. Google Scholar 8 : Clinical use of prostate specific antigen with prostate cancer. J. Urol.1989; 142: 1011. Abstract, Google Scholar 9 : Keratin immunoreactivity in the benign and neoplastic human prostate. Cancer Res.1985; 45: 3663. Google Scholar From the Division of Urology and Cardiac Surgery, Hospital Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 159Issue 3March 1998Page: 875-877 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information NELSON RODRIGUES NETTO More articles by this author MARCELO LOPES LIMA More articles by this author MARCOS A. GUEDES More articles by this author LUIS LARCO PATINO More articles by this author JOAO BOSCO de OLIVEIRA More articles by this author Expand All Advertisement PDF downloadLoading ...