The athymic nude rat Immunobiological characteristics with special reference to establishment of non‐antigen‐specific T‐cell reactivity and induction of antigen‐specific immunity
1991; Wiley; Volume: 99; Issue: S21 Linguagem: Inglês
10.1111/j.1600-0463.1991.tb05751.x
ISSN1600-0463
Autores Tópico(s)Drug-Induced Hepatotoxicity and Protection
ResumoAPMISVolume 99, Issue S21 p. 9-39 The athymic nude rat Immunobiological characteristics with special reference to establishment of non-antigen-specific T-cell reactivity and induction of antigen-specific immunity HANS PETTER HOUGEN, HANS PETTER HOUGEN Bartholin Instituttet and University Institute of Forensic Pathology, Copenhagen, Denmark.Search for more papers by this author HANS PETTER HOUGEN, HANS PETTER HOUGEN Bartholin Instituttet and University Institute of Forensic Pathology, Copenhagen, Denmark.Search for more papers by this author First published: February 1991 https://doi.org/10.1111/j.1600-0463.1991.tb05751.xCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Araujo, F. G.: Development of resistance to trypanosoma cruzi in mice depends on a viable population of L3T4+ (CD4+) lymphocytes. Infect. Immun. 57: 2246–2248, 1989. PubMedWeb of Science®Google Scholar 2 Bach, J.-F.: Thymulin (FTS-Zn). In: J.-F. Bach (Eds.): Clinics in immunology and allergy. Saunders, London 1983, vol. 3, pp. 133–156. Web of Science®Google Scholar 3 Bach, J.-F.: The plurality of thymic hormones. In: J.-F. Bach (Eds.): Clinics in immunology and allergy. Saunders, London 1983, vol. 3, pp. 197–200. Web of Science®Google Scholar 4 Bell, E. B., Sparshott, S. M., Drayson, M. T. & Ford, W. L.: The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells. J. Immunol. 139: 1379–1384, 1987. CASPubMedWeb of Science®Google Scholar 5 Bell, E. B.: Thymus-derived and non-thymus-derived T-like cells. The origin and function of cells bearing τβ receptors. Thymus: 14: 3–17, 1989. CASPubMedWeb of Science®Google Scholar 6 Berridge, M. V., O'Kech, N., McNeilage, L. J., Heslop, B. F. & Moore, R.: Rat mutant (NZNU) showing "nude" characteristics. Transplantation 6: 410–413, 1979. Google Scholar 7 Brooks, C. G., Webb, P. J., Robins, R. A., Robinson, G., Baldwin, R. W. & Festing, M. F. W.: Studies on the immuno-biology of rnu/rnu "nude" rats with congenital aplasia of the thymus. Eur. J. Immunol. 10: 58–65, 1980. 10.1002/eji.1830100112 CASPubMedWeb of Science®Google Scholar 8 Buschard, K.: Det thymusafhængige immunapparat i pato-genesen til type 1 (insulin-krævende) diabetes mellitus. Lægeforeningens Forlag, 1984. Google Scholar 9 Carthew, P. & Sparrow, S.: Sendai virus in nude and germ-free rats. Res. Vet. Sc. 29: 289–292, 1980. 10.1016/S0034-5288(18)32629-8 CASPubMedWeb of Science®Google Scholar 10 Cruickshank, J. K., Price, K. M., Mackenzie, C. D., Spry, C. J. F. & Denham, D. A.: Infection of inbred and nude (athymic) rats with Brugia spp. Parasite Immunol. 5: 527–537, 1983. 10.1111/j.1365-3024.1983.tb00769.x CASPubMedWeb of Science®Google Scholar 11 Dardenne, M. & Bach, J. F.: Thymic hormone in the treatment of cancer. Prg. Clin. Biol. Res. 288: 363–382, 1989. CASGoogle Scholar 12 De Geus, B, Van den Enden, M, Coolen, C. & Rozing, J.: Localization and phenotype of CD3 associated gamma/delta receptor expressing intestinal intraepithelial lymphocytes. Thymus 14: 31–41, 1989. PubMedWeb of Science®Google Scholar 13 De Geus, B, Van den Enden, M, Coolen, C., Nagelkerken, L., Van der Heijden, P & Rozing, J.: Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: implications for differentiation of cells bearing a CD3-associated τδ T cell receptor. Eur. J. Immunol. 20: 291–298, 1990. 10.1002/eji.1830200210 PubMedWeb of Science®Google Scholar 14 De Maagd, R. A., Mackenzie, W. A., Schuurman, H.-J., Ritter M. A., Price, K. M., Broekhuizen, R. & Kater, L: The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies. Immunol. 54: 745–754, 1985. PubMedWeb of Science®Google Scholar 15 De Jong, W. H., Steerenberg, P. A., Ursem, P. S., Osterhaus, A. D. M. E., Vos, J. G. & Ruitenberg, E. J.: The athymic nude rat. III. Natural cell-mediated cytotoxicity. Clin. Immunol. Immunopathol. 17: 163–172, 1980. 10.1016/0090-1229(80)90084-7 CASPubMedWeb of Science®Google Scholar 16 De Weger, R. A., Van Loveren, H., Vandebriel, R. J. & Parmentier, K.: Sequential activity of gamma-delta T-cell receptor bearing lymphocytes, specific T-cell factors, and alpha-beta T-cell receptor bearing T-cells. A hypothesis. Thymus, 14: 19–29, 1989. PubMedWeb of Science®Google Scholar 17 Douglas-Jones, A., Nelson, J., Jansen, V. & Miller, Th.: Characterization of the (rnunz) nude rat. Morphological characteristics of the lymphoid system. AJEBAK 59: 277–286, 1981. CASPubMedWeb of Science®Google Scholar 18 Ferrick, D. A., Ohashi, P. S., Wallace, V., Schilham, M. & Mak, T. W.: Thymic ontogeny and selection of αβ and τδ T cells. Immunology Today 10: 403–407, 1989. 10.1016/0167-5699(89)90035-2 CASPubMedWeb of Science®Google Scholar 19 Festing, M. F. W., May, D., Connors, T. A., Lovell, D. & Sparrow, S.: An athymic nude mutation in the rat. Nature 274: 365–366, 1978. 10.1038/274365a0 CASPubMedWeb of Science®Google Scholar 20 Fossum, S., Smith, M. E., Bell, E. B. & Ford, W. L.: The architecture of rat lymph nodes. III. The lymph nodes and lymph-borne cells of the congenitally athymic nude rat (rnu). Scand. J. Immunol. 12: 421–432, 1980. 10.1111/j.1365-3083.1980.tb00086.x CASPubMedWeb of Science®Google Scholar 21 Fossum, S.: The density and distribution of W3/13, OX19, W3/25, and OX8 positive cells in nude rat (rnu) lymph nodes. Transpl. Proc. 2: 1638–1639, 1983. Google Scholar 22 Fossum, S., Smith, M. E. & Ford, W. L.: The migration of lymphocytes across specialized vascular endothelium. VII. The migration of T and B lymphocytes from the blood of the athymic, nude rat. Scand. J. Immunol. 17: 539–549, 1983. 10.1111/j.1365-3083.1983.tb00822.x CASPubMedWeb of Science®Google Scholar 23 Fossum, S., Smith, M. E. & Ford, W. L.: The recirculation of T and B lymphocytes in the athymic nude rat. Scand. J. Immunol. 17: 551–557, 1983. 10.1111/j.1365-3083.1983.tb00823.x CASPubMedWeb of Science®Google Scholar 24 Fossum, S. & Ford, W. L.: The organization of cell populations within lymph nodes: their origin, life history and functional relationships. Histopathol. 9: 469–499, 1985. 10.1111/j.1365-2559.1985.tb02830.x PubMedWeb of Science®Google Scholar 25 Fossum, S. & Rolstad, B.: The roles of interdigitating cells and natural killer cells in the rapid rejection of allogeneic lymphocytes. Eur. J. Immunol. 16: 440–450, 1986. 10.1002/eji.1830160422 PubMedWeb of Science®Google Scholar 26 Gaertner, D. J., Jacoby, R. O., Smith, A. L., Ardito, R. B. & Paturzo, F. X.: Persistence of rat parvovirus in athymic rats. Arch. Virol 105: 259–268, 1989. 10.1007/BF01311362 CASPubMedWeb of Science®Google Scholar 27 Gilhar, A., Wojciechowski, Z. J., Piepkom, M. W., Spangrude, G. J., Roberts, L. K. & Krueger, G. G.: Description of and treatment to inhibit the rejection of human split-thickness skin grafts by congenitally athymic (nude) rats. Expl. Cell. Biol. 54: 263–274, 1986. CASPubMedWeb of Science®Google Scholar 28 Goldstein, A. L., Low, T. L., Zatz, M. M., Hall, N. R. & Naylor, P. H.: Thymosins. In: J.-F. Bach (Eds.): Clinics in immunology and allergy. Saunders, London 1983, vol. 3, pp. 119–132. Web of Science®Google Scholar 29 Good, R. A.: The thymus and its hormones. In: J.-F. Bach (Eds.): Clinics in immunology and allergy. Saunders, London 1983, vol. 3, pp. 3–7. Web of Science®Google Scholar 30 Green III, F., Weber, J. K. & Balish, E.: The thymus dependency of acquired resistance to Trichophyton mentagrophytes dermatophytosis in rats. J. Invest. Dermatol. 81: 31–38, 1987. 10.1111/1523-1747.ep12538364 PubMedWeb of Science®Google Scholar 31 Græm, N.: Virkningen af ultraviolet lys B, TPA og DMBA på epidermis af heterotransplanteret human hud. Lægeforeningens Forlag, 1987. Google Scholar 32 Hammar, J. A.: Über Gewicht, Involution und Persistenz der Thymus im Postfötalleben des Menschen. Arch. Anat. Entwicklungsgesch. Suppl.: 91–182, 1906. Google Scholar 33 Haynes, B. F., Denning, S. M., Singer, K. H. & Kurtzberg, J.: Ontogeny of T-cell precursors: a model for the initial stages of human T-cell development. Immunology Today 10: 87–91, 1989. 10.1016/0167-5699(89)90232-6 PubMedWeb of Science®Google Scholar 34 Hinrichs, D. J. & Humphres, R. C.: The response of the nude (athymic) rat to actively induced and adoptively transferred experimental allergic encephalomyelitis. J. Immunol. 1: 4–5, 1983. Google Scholar 35 Hougen, H. P. & Klausen, B.: Effects of homozygosity of the nude (rnu) gene in an inbred strain of rats: Studies of lymphoid and non-lymphoid organs in different age groups of nude rats of LEW background at a stage in the gene transfer. Lab. Animals 18: 7–14, 1984. 10.1258/002367784780865018 CASPubMedWeb of Science®Google Scholar 36 Hougen, H. P., Klausen, B., Stenvang, J. P., Krœmmer, J. & Rygaard, J.: Effects of xenogeneic, allogenic and isogeneic thymus grafts on lymphocyte populations in peripheral lymphoid organs of the nude rat. Lab. Animals 21: 103–111, 1987. 10.1177/002367728702100204 PubMedWeb of Science®Google Scholar 37 Hougen, H. P. & Klausen, B.: The thymus reconstituted nude rat: Lymphocyte subpopulations and immunological characteristics. Thymus 10: 207–217, 1987. PubMedWeb of Science®Google Scholar 38 Hougen, H. P., Jensen, E. T. & Klausen, B.: Experimental Salmonella typhimurium infection in rats. I: Influence of thymus on the course of infection. APMIS 97: 825–832, 1989. 10.1111/j.1699-0463.1989.tb00484.x CASPubMedWeb of Science®Google Scholar 39 Hougen, H. P., Klausen, B. & Jensen, E. T.: Are CD4+ cells responsible for protection against salmonellosis? Remarks from studies on athymic and thymus-grafted rats. Thymus 13: 213–215, 1989. CASPubMedWeb of Science®Google Scholar 40 Hougen, H. P., Jensen, E. T. & Klausen, B.: Experimental Salmonella typhimurium infections in rats. II. Active and passive immunization as protection against a lethal bacterial dose. APMIS 98: 30–36, 1990. 10.1111/j.1699-0463.1990.tb00998.x CASPubMedWeb of Science®Google Scholar 41 Hougen, H. P. & Jensen, E. T.: Experimental Salmonella typhimurium infections in rats. III. Transfer of immunity with primed lymphocyte subpopulations. APMIS, 98: 1015–1021, 1990. 10.1111/j.1699-0463.1990.tb05028.x CASPubMedWeb of Science®Google Scholar 42 Hünig, T., Wallny, H.-J., Hartley, J. K., Lawetzky, A. & Tie-fenthaler, G.: A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. J. Exp. Med. 169: 73–86, 1989. 10.1084/jem.169.1.73 PubMedWeb of Science®Google Scholar 43 Jacobson, E. B., Caporale, L. H. & Thorbecke, G. J.: Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice. Cell. Immunol. 13: 416–430, 1974. 10.1016/0008-8749(74)90261-5 CASPubMedWeb of Science®Google Scholar 44 Janeway Jr., C. A., Jones, B. & Hayday, A.: Specificity and function of T cells bearing τδ receptors. Immunology Today 9: 73–76, 1988. 10.1016/0167-5699(88)91267-4 PubMedWeb of Science®Google Scholar 45 Kamiyama, T., Cortes, G. T. & Rubio, Z.: The role of thymocytes and IgG antibody in protection against malaria in nude rats. Zbl. Bakt. Hyg. A 264: 496–501, 1987. CASPubMedWeb of Science®Google Scholar 46 Kampinga, J., Pol, G. H., Bartels, H., Duijvestijn, A. M., Murawska, M. B., van de Berk, J. M. M. M. & Nieuwenhuis, P.: Vascular thymus transplantation in rats: A new method to study thymocyte kinetics. In: S. Fossum & B. Rolstad (Eds.): Advances in Exp. Med. and Biol. Histophysiology of the immune system. Plenum Press, NY London 1988, pp. 333–338. 10.1007/978-1-4684-5535-9_49 Google Scholar 47 Kampinga, J., Berges, S., Boyd, R. L., Brekelmans, P., Colic, M., Van Ewijk, W., Kendall, M. D., Ladyman, H., Nieuwenhuis, P., Ritter, M. A., Schuurman, H.-J. & Tournefier, A.: Thymic epithelial antibodies: Immunohistological analysis and introduction of nomenclature. Thymus 13: 165–173, 1989. CASPubMedWeb of Science®Google Scholar 48 Kaufmann, S. H. E., Simon, M. M. & Hahn, H.: Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens. J. Exp. Med. 150: 1033–1038, 1979. 10.1084/jem.150.4.1033 CASPubMedWeb of Science®Google Scholar 49 Kaufmann, S. H. E.: CD8+ T lymphocytes in intracellular microbial infections. Immunology Today 9: 168–174, 1988. 10.1016/0167-5699(88)91292-3 PubMedWeb of Science®Google Scholar 50 Kendall, M. D., Schuurman, H.-J., Fenton, J., Broekhuizen, R. & Kampinga, J.: Implantation of cultured thymic fragments in congenitally athymic (nude rats). Ultrastructural characteristics of the developing microenvironment. Cell Tissue Res. 254: 283–294, 1988. 10.1007/BF00225801 CASPubMedWeb of Science®Google Scholar 51 Klausen, B., Hougen, H. P. & Rygaard, J.: Induction of plaque-forming cell response in adrenalectomized nude rats using thymosin fraction 5. Acta path. microbiol. immunol. scand. sect. C 90: 283–284, 1982. CASPubMedWeb of Science®Google Scholar 52 Klausen, B., Hougen, H. P., Eriksen, W. H. & Fiehn, N.-E.: Induction of periodontal bone loss in athymic (nude) rats monoinfected with Streptococcus mutans. J. Periodont. Res. 21: 5–12, 1986. 10.1111/j.1600-0765.1986.tb01431.x PubMedGoogle Scholar 53 Klausen, B. & Hougen, H. P.: Quantitative studies of lymphoid organs, blood and lymph in inbred athymic and euthymic LEW rats under germfree and specified-pathogen-free conditions. Lab. Animals 21: 342–357, 1987. 10.1258/002367787781363318 CASPubMedWeb of Science®Google Scholar 54 Klausen, B., Hougen, H. P. & Fiehn, N.-E.: Increased periodontal bone loss in temporarily B lymphocyte-deficient rats. J. Periodont. Res. 24: 384–390, 1989. 10.1111/j.1600-0765.1989.tb00887.x PubMedWeb of Science®Google Scholar 55 Koninkx, J. E. J. G., Schreurs, A. J. M., Penninks, A. H. & Seinen, W.: Induction of postthymic T-cell maturation by thymic humoral factor(s) derived from a tumor cell of thymic epithelial origin. Thymus 6: 395–409, 1984. CASPubMedWeb of Science®Google Scholar 56 Kumararatne, D. S., Bazin, H. & MacLennan, J. C. M.: Marginal zones: the major B cell compartment of rat spleen. Eur. J. Immunol. 11: 858–864, 1981. 10.1002/eji.1830111103 PubMedWeb of Science®Google Scholar 57 Kyewski, B.: Unravelling the complexity of intrathymic cell-cell interactions. APMIS 96: 1049–1060, 1988. 10.1111/j.1699-0463.1988.tb00980.x CASPubMedWeb of Science®Google Scholar 58 Lotzova, E., Savary, C. A., Stringfellow, D. A., Drewinko, B., Gray, K. N., Raulston, G. L. & Jardine, J. H.: Analysis of natural killer cell activity in random-bred rowett athymic rats. Expl. Cell. Biol. 52: 53–59, 1984. CASWeb of Science®Google Scholar 59 Marshall, E. & Miller, Th.: Characterization of the nude rat (rnunz). Functional characteristics. AJEBAK 59: 287–296, 1981. CASPubMedWeb of Science®Google Scholar 60 Mitchell, G. F., Anders, R. F., Brown, G. V., Handman, E., Roberts - Thomson, I. C., Chapman, C. B., Forsyth, K. P., Kahl, L. P. & Cruise, K. M.: Analysis of infection characteristics and antiparasite immune responses in resistant compared with susceptible hosts. Immunol. Rev. 61: 138–170, 1982. 10.1111/j.1600-065X.1982.tb00376.x Web of Science®Google Scholar 61 Morrison, W. I., Goddeeris, B. M., Teale, A. J., Baldwin, C. L., Bensaid, A. & Ellis, J.: Cell-mediated immune responses of cattle to Theileria parva. Immunology Today 7: 211–216, 1986. 10.1016/0167-5699(86)90107-6 PubMedWeb of Science®Google Scholar 62 Nencioni, L., Villa, L., Boraschi, D., Berti, B. & Tagliabue, A.: Natural and antibody-dependent cell-mediated activity against Salmonella typhimurium by peripheral and intestinal lymphoid cells in mice. J. Immunol. 130: 903–907, 1983. PubMedWeb of Science®Google Scholar 63 Parrott, D. M. V., De Souse, M. A. B. & East, J.: Thymus-dependent areas in the lymphoid organs of neonatally thymectomized mice. J. Exp. Med. 123: 191–203, 1966. 10.1084/jem.123.1.191 CASPubMedWeb of Science®Google Scholar 64 Perrudet-Badoux, A., Ruitenberg, E. J. & Elgersma, A.: Preliminary studies on the course of a Trichinella spiralis infection in athymic, nude rats. J. Parasitol. 66: 671–672, 1980. 10.2307/3280528 CASPubMedWeb of Science®Google Scholar 65 Phillips, S. M., Walker, D., Abdel-Hafez, S. K., Lineette, G. P., Doughty, B. L., Perrin, P. J. & Fathelbab, N: The immune response to Schistosoma mansoni infections in inbred rats. VI. Regulation by T cell subpopulations. J. Immunol. 139: 2781–2787, 1987. CASPubMedWeb of Science®Google Scholar 66 Pritchard, K. E. & Eady, R. P.: Some aspects of immunology in the nude rat. In: S. Sparrow (Eds.): Immunodeficient animals for cancer research. The Macmillan Press LTD, London and Basingstoke 1980, pp. 67–79. 10.1007/978-1-349-05014-7_6 Google Scholar 67 Reynolds, C. W., Timonen, T. T., Holden, T. H., Hansen, C. T. & Herberman, R. B.: Natural killer cell activity in the rat. Analysis of effector cell morphology and effects of interferon on natural killer cell function in the athymic (nude) rat. Eur. J. Immunol. 12: 577–582, 1982. 10.1002/eji.1830120709 CASPubMedWeb of Science®Google Scholar 68 Ridge, S. C., Zabriske, J. B., Oronsky, A. L. & Kerwar, S. S.: Streptococcal cell wall arthritis: Studies with nude (athymic) inbred Lewis rats. Cell. Immunol. 96: 231–234, 1985. 10.1016/0008-8749(85)90354-5 CASPubMedWeb of Science®Google Scholar 69 Ritter, M. A., Rozing, J. & Schuurman, H.-J.: The true function of the thymus?. Immunology Today 9: 189–193, 1988. 10.1016/0167-5699(88)91208-X CASPubMedWeb of Science®Google Scholar 70 Rodriguez, A. M., Afchain, D., Santoro, F., Bazin, H. & Capron, A.: Parasitological and immunological aspects of Trypanosoma cruzi infection in nude rats. Z. Parasitenkd. 69: 141–147, 1983. 10.1007/BF00926950 CASPubMedWeb of Science®Google Scholar 71 Rolstad, B. & Ford, W. L.: The rapid elimination of allogeneic lymphocytes: relationship to established mechanisms of immunity and to lymphocyte traffic. Immunol. Rev. 73: 87–113, 1983. 10.1111/j.1600-065X.1983.tb01080.x PubMedWeb of Science®Google Scholar 72 Rolstad, B., Fossum, S., Tønnesen, B. & Ford, W. L.: Athymic nude rats resist graft-versus-host disease because they reject allogeneic lymphocytes. Transpl. Proc. 15: 1656–1657, 1983. Web of Science®Google Scholar 73 Rolstad, B.: Immune responses to Legionella pneumophila in athymic nude rats. Acta path. microbiol. scand. sect. C 92: 233–236, 1984. CASPubMedWeb of Science®Google Scholar 74 Rolstad, B. & Fossum, S.: Allogeneic lymphocyte cytotoxicity (ALC) in rats: establishment of an in vitro assay, and direct evidence that cells with natural killer (NK) activity are involved in ALC. Immunol. 60: 151–157, 1987. PubMedWeb of Science®Google Scholar 75 Rose, M. E., Ogilvie, B. M., Hesketh, P. & Festing, M. F. W.: Failure of nude (athymic) rats to become resistant to reinfection with the intestinal coccidian parasite Eimeria nieschulzi or the nematode Nippostrongylus brasiliensis. Parasite Immunol. 1: 125–132, 1979. 10.1111/j.1365-3024.1979.tb00700.x PubMedGoogle Scholar 76 Rygaard, J.: Thymus and self. Immunobiology of the mouse mutant nude. FADL, Copenhagen, 1973. Google Scholar 77 Sadler, T. W.: Langman's medical embryology. 5th edition. Williams & Wilkins, Baltimore, 1985. Google Scholar 78 Sainte-Marie, G., Pelletier, M. & Peng, F.-S.: Modifications of the structures of the rat lymph nodes by neonatal thymectomy. Thymus 6: 309–323, 1984. CASPubMedWeb of Science®Google Scholar 79 Salomon, J.-C. & Fogh, J.: The nude rat. In: J. Fogh & B. C. Giovanella (Eds.): The nude mouse in experimental and clinical research. Acad. Press, NY 1982, vol. 2, pp. 229–245. Google Scholar 80 Schafer, R., Nacy, C. A. & Eisenstein, T. K.: Induction of activated macrophages in C3H/HeJ mice by avirulent Salmonella. J. Immunol. 140: 1638–1644, 1988. CASPubMedWeb of Science®Google Scholar 81 Schuurman, H.-J., Vos, J. G., van de Brink, E & Kater, L.: Culture of thymic epithelium for transplantation purposes: morphological characterization and in vivo biological effect on thymus-dependent immunity in athymic (nude) rats. Clin. Immunol. Immunopathol. 24: 418–431, 1982. 10.1016/0090-1229(82)90012-5 PubMedWeb of Science®Google Scholar 82 Schuurman, H.-J., Vos, J. G. & Kater, L.: Induction of thymus-dependent immunity in athymic nude rats by transplantation of allogeneic cultured thymic epithelium. Expl. Cell. Biol. 52: 103–106, 1984. CASPubMedWeb of Science®Google Scholar 83 Schuurman, H.-J., Vos, J. G., Broekhuizen, R., Brandt, C. J. W. M. & Kater, L.: In vivo biological effect of allogeneic cultured thymic epithelium on thymus-dependent immunity in athymic nude rats. Scand. J. Immunol. 21: 21–30, 1985. 10.1111/j.1365-3083.1985.tb01398.x CASPubMedWeb of Science®Google Scholar 84 Schuurman, H.-J., Vaessen, L. M. B., Vos, J. G., Hertogh, A., Geertzema, J. G. N., Brandt, C. J. W. M. & Rozing, J.: Implantation of cultured thymic fragments in congenitally athymic nude rats: ignorance of thymic epithelial haplotype in generation of alloreactivity. J. Immunol. 137: 2440–2447, 1986. CASPubMedWeb of Science®Google Scholar 85 Schuurman, H.-J., Vaessen, L. M. B., Broekhuizen, R., Brandt, C. J. W. M., Holewijn, M. C., Vos, J. G. & Rozing, J.: Implantation of cultured thymic fragments in congenitally athymic (nude) rats. Scand. J. Immunol. 26: 129–139, 1987. 10.1111/j.1365-3083.1987.tb02245.x CASPubMedWeb of Science®Google Scholar 86 Schuurman, H.-J., Kampinga, J., Rozing, J. & Vos, J.G.: Thymus implantation in nude rats: Biological effects of the microenvironment or of lymphocytes?. Thymus 11: 261–265, 1988. CASPubMedWeb of Science®Google Scholar 87 Schuurman, H.-J., Rozing, J., Van Loveren, H., Vaessen, L. M. B. & Kampinga, J.: The congenitally athymic nude rat. Studies on thymus-dependent immune competence during aging and after thymus implantation. In: B.-q Wu & J. Zheng (Eds.): Immune-deficient animals in experimental medicine. Karger, Basel 1989, pp. 54–62. Google Scholar 88 Sfaksi, A., Bonneville, M. & Soulillou, J. P.: Cellular immune response in rnu/rnu rats. I. Lectin responsiveness and IL-2 production kinetics of natural cytotoxicity and spleen-cell surface marker expression. Immunol. 55: 655–662, 1985. CASPubMedWeb of Science®Google Scholar 89 Taubman, M. A., Ebersole, J. L. & Smith, D. J.: Immunoglobulins of rnu/rnu "nude" rats with congenital aplasia of the thymus. Immunol. 49: 295–300, 1983. CASPubMedWeb of Science®Google Scholar 90 Tønnesen, B. & Rolstad, B.: In vivo elimination of allogeneic lymphocytes in normal and T-cell-deficient rats. Elimination does not require T cells. Scand. J. Immunol. 17: 303–312, 1983. 10.1111/j.1365-3083.1983.tb00794.x CASPubMedWeb of Science®Google Scholar 91 Vaessen, L. M. B., Broekhuizen, R., Rozing, J., Vos, J.G. & Schuurman, H.-J.: T-cell development during ageing in congenitally athymic (nude) rats. Scand. J. Immunol 24: 223–235, 1986. 10.1111/j.1365-3083.1986.tb02089.x CASPubMedWeb of Science®Google Scholar 92 Van Deurs, B. & Röpke, C.: The postnatal development of high-endothelial venules in lymph nodes of mice. Anat. Rec. 181: 659–678, 1974. 10.1002/ar.1091810308 PubMedWeb of Science®Google Scholar 93 Van Loveren, H., Schuurman, H.-J., Vos, J.G.: Immune deficiency sydrome in rodents: the nude rat. In: A. C. Beynen & H. A. Solleveld (Eds.): New Developments in bio-sciences: Their implications for laboratory animal science. Martinus Nijhoff, Dordrecht, 1988, pp. 17–28. 10.1007/978-94-009-3281-4_4 Google Scholar 94 von Boehmer, H: The developmental biology of T lymphocytes. Ann. Rev. Immunol. 6: 309–326, 1988. 10.1146/annurev.iy.06.040188.001521 PubMedWeb of Science®Google Scholar 95 von Boehemer, H, Teh, H. S. & Kisielow, P.: The thymus selects the useful, neglects the useless and destroys the harmful. Immunology Today 10: 308–315, 1988. Google Scholar 96 von Gaudecker, B: The development of human thymus microen microenvironment. Curr. Top. Pathol. 75: 1–41, 1986. 10.1007/978-3-642-82480-7_1 Google Scholar 97 Vos, J.G., Buys, J., Beekhof, P. & Hagenaars, A. M.: Quantification of total IgM and IgG and specific IgM and IgG to a thymus-independent (lps) and a thymus-dependent (tetanus toxoid) antigen in the rat by enzyme-linked immunosorbent assay (elisa). Ann. N.Y. Acad. Sci. 320: 518–534, 1979. 10.1111/j.1749-6632.1979.tb56631.x CASPubMedGoogle Scholar 98 Vos, J. G., Berkvens, J. M. & Kruijt, B. C.: The athymic nude rat. I. Morphology of lymphoid and endocrine organs. Clin. Immnol. Immunopathol. 15: 213–228, 1980. 10.1016/0090-1229(80)90032-X CASPubMedWeb of Science®Google Scholar 99 Vos, J. G., Kreeftenberg, J. G., Kruijt, B. C., Kruizinga, W. & Steerenberg, P.: The athymic nude rat. II. Immunological characteristics. Clin. Immunol. Immunopathol. 15: 229–237, 1980. 10.1016/0090-1229(80)90033-1 CASPubMedWeb of Science®Google Scholar 100 Vos, J. G., Ruitenberg, E. J., Van Basten, N., Buys, J., Elgersma A. & Kruizinga, W. K.: The athymic nude rat. IV. Immunocytochemical study to detect T-cells, and immunological and histopathological reactions against Trichinella spiralis. Parasite Immunol. 5: 195–215, 1983. 10.1111/j.1365-3024.1983.tb00737.x PubMedWeb of Science®Google Scholar 101 Weissman, I. L., Gutman, G. A., Friedberg, S. H. & Jerabek, L.: Lymphoid tissue architecture. III. germinal centers, T cells, and thymus-dependent vs. thymus-independent antigens. In: M. Feldman & A. Globerson (Eds.): Advances in experimental medicine and biology. Plenum Press, NY & London 1976, vol. 66, pp. 229–237. Google Scholar 102 Willcox, N., Schluep, M., Ritter, M. A., Schuurman, H.-J., Newsom -Davis, J & Christensson, B.: Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial subset?. Am. J. Pathol. 127: 447–460, 1987. CASPubMedWeb of Science®Google Scholar 103 Wonigeit, K., Hedrich, H.J., Schwinzer, R.: Demonstration of alloreactive T cells and allogenic skin graft rejection in athymic nude rats. In: J. Rygaard, N. Brünner, N. Græm & M. Spang-Thomsen (Eds.): Immune-deficient animals in biomedical research. Karger, Basel 1987, pp. 85–88. Google Scholar 104 Yoshie, H., Taubman, M. A., Ebersole, J. L., Smith, D. J. & Olson, C. L.: Periodontal bone loss and immune characteristics of congenitally athymic and thymus cell-reconstituted athymic rats. Infect. Immun. 50: 403–408, 1985. 10.1128/IAI.50.2.403-408.1985 CASPubMedWeb of Science®Google Scholar Citing Literature Volume99, IssueS21February 1991Pages 9-39 ReferencesRelatedInformation
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