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Treatment of trophoblastic disease

1966; Elsevier BV; Volume: 96; Issue: 5 Linguagem: Inglês

10.1016/0002-9378(66)90423-6

1097-6868

John Lewis, Hazel Gore, Arthur T. Hertig, Donald A. Goss,

Gestational Trophoblastic Disease Studies

The results of therapy in 16 patients with metastatic or nonmetastatic trophoblastic disease have been reported. Therapy consisted of chemotherapy alone or chemotherapy with indicated surgery carried out in the middle of a course of drug administration. Agents used were Methotrexate and actinomycin D. A complete remission rate of 75 per cent among 8 patients with metastatic trophoblastic disease and 100 per cent among 8 patients with nonmetastatic disease is recorded. The rationale and feasibility of operating during a course of "adjunctive" chemotherapy are discussed. In this series there was no evidence of delay in wound healing nor spread of disease following the 13 surgical procedures carried out under cover of chemotherapy in 11 of this group of 16 patients. No claim is made in regard to the relative efficacy of this type of combined therapy and chemotherapy alone.