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PSYCHOMETRIC ANALYSIS OF THE UNIVERSITY OF WISCONSIN INTERSTITIAL CYSTITIS SCALE: IMPLICATIONS FOR USE IN RANDOMIZED CLINICAL TRIALS

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 3 Linguagem: Inglês

10.1016/s0022-5347(01)63840-0

1527-3792

JAMES E. GOIN, DAVID OLALEYE, Kenneth M. Peters, Bruce W. Steinert, KATHY HABICHT, GORDON WYNANT,

Urological Disorders and Treatments

No AccessJournal of UrologyInvestigative Urology1 Mar 1998PSYCHOMETRIC ANALYSIS OF THE UNIVERSITY OF WISCONSIN INTERSTITIAL CYSTITIS SCALE: IMPLICATIONS FOR USE IN RANDOMIZED CLINICAL TRIALS JAMES E. GOIN, DAVID OLALEYE, KENNETH M. PETERS, BRUCE STEINERT, KATHY HABICHT, and GORDON WYNANT JAMES E. GOINJAMES E. GOIN , DAVID OLALEYEDAVID OLALEYE , KENNETH M. PETERSKENNETH M. PETERS , BRUCE STEINERTBRUCE STEINERT , KATHY HABICHTKATHY HABICHT , and GORDON WYNANTGORDON WYNANT View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63840-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: A psychometric analysis of the University of Wisconsin Interstitial Cystitis Scale was conducted on 30 females previously enrolled in a phase II double-blind randomized controlled trial evaluating the efficacy of six weekly intravesical instillations of TICE [R] BCG. The analyses were to: (1) evaluate the adequacy of the seven individual IC component items for measuring the range of patient responses; (2) verify the 2-factor (IC versus reference) construct of the scale; (3) evaluate the internal consistency and reliability of the IC items; (4) better define the scale's applicability and limitations; and (5) if possible, make recommendations for improvements in the scale. Materials and Methods: Standard psychometric analyses were used to perform the evaluation, and included descriptive analysis of individual items, computing of item-total correlations and Cronbach's internal consistency measures, and the application of factor and Rasch analyses. Results: The original 7-item IC scale was found to have ceiling effects that could limit its use in detecting small therapeutic differences. It was also found that the Pelvic item originally assigned to the reference set of items of the scale should be included as an IC item when used in a comparable IC population. After including this item into the IC scale Cronbach's alpha was 0.84, compared with 0.82. Conclusions: The UW-IC Scale has psychometric properties similar to other measurement instruments used in clinical research, and appears worthy of further study in well-characterized IC populations. The reference items suggest that IC patients do not indiscriminately report high values for generalized body complaints, but do so on bladder related symptoms as recorded by the IC items of the scale. Although the scale has limitations it appears applicable for use in future IC intervention clinical trials. References 1 : Interstitial cystitis-still an enigma after 80 years. Br. J., Obstet, Gynaecol.1996; 103: 621. 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Google Scholar From the DataMedix Corporation, Wayne, Pennsylvania, the Department of Urology, William Beaumont Hospital, Royal Oak, Michigan, and PerImmune, Inc., Rockville, Maryland.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByFoster H, Hanno P, Nickel J, Payne C, Mayer R, Burks D, Yang C, Chai T, Kreder K, Peters K, Lukacz E, FitzGerald M, Cen L, Landis J, Propert K, Yang W, Kusek J and Nyberg L (2018) Effect of Amitriptyline on Symptoms in Treatment Naïve Patients With Interstitial Cystitis/Painful Bladder SyndromeJournal of Urology, VOL. 183, NO. 5, (1853-1858), Online publication date: 1-May-2010.Propert K, Mayer R, Nickel J, Payne C, Peters K, Teal V, Burks D, Kusek J, Nyberg L and Foster H (2018) Followup of Patients With Interstitial Cystitis Responsive to Treatment With Intravesical Bacillus Calmette-Guerin or PlaceboJournal of Urology, VOL. 179, NO. 2, (552-555), Online publication date: 1-Feb-2008.Erickson D, Kunselman A, Bentley C, Peters K, Rovner E, Demers L, Wheeler M and Keay S (2018) Changes in Urine Markers and Symptoms After Bladder Distention for Interstitial CystitisJournal of Urology, VOL. 177, NO. 2, (556-560), Online publication date: 1-Feb-2007.Nickel J, Tripp D, Teal V, Propert K, Burks D, Foster H, Hanno P, Mayer R, Payne C, Peters K, Kusek J and Nyberg L (2018) Sexual Function is a Determinant of Poor Quality of Life for Women With Treatment Refractory Interstitial CystitisJournal of Urology, VOL. 177, NO. 5, (1832-1836), Online publication date: 1-May-2007.Propert K, Mayer R, Nickel J, Payne C, Peters K, Teal V, Burks D, Kusek J, Nyberg L and Foster H (2018) Did Patients With Interstitial Cystitis Who Failed to Respond to Initial Treatment With Bacillus Calmette-Guerin or Placebo in a Randomized Clinical Trial Benefit From a Second Course of Open Label Bacillus Calmette-Guerin?Journal of Urology, VOL. 178, NO. 3, (886-890), Online publication date: 1-Sep-2007.Lokeshwar V, Selzer M, Unwala D, Estrella V, Gomez M, Golshani R, Kester R, Klumpp D and Gousse A (2018) Uronate Peaks and Urinary Hyaluronic Acid Levels Correlate With Interstitial Cystitis SeverityJournal of Urology, VOL. 176, NO. 3, (1001-1007), Online publication date: 1-Sep-2006.CLEMENS J, MEENAN R, ROSETTI M, GAO S and CALHOUN E (2018) PREVALENCE AND INCIDENCE OF INTERSTITIAL CYSTITIS IN A MANAGED CARE POPULATIONJournal of Urology, VOL. 173, NO. 1, (98-102), Online publication date: 1-Jan-2005.ERICKSON D, TOMASZEWSKI J, KUNSELMAN A, BENTLEY C, PETERS K, ROVNER E, DEMERS L, WHEELER M and KEAY S (2018) DO THE NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES CYSTOSCOPIC CRITERIA ASSOCIATE WITH OTHER CLINICAL AND OBJECTIVE FEATURES OF INTERSTITIAL CYSTITIS?Journal of Urology, VOL. 173, NO. 1, (93-97), Online publication date: 1-Jan-2005.MAYER R, PROPERT K, PETERS K, PAYNE C, ZHANG Y, BURKS D, CULKIN D, DIOKNO A, HANNO P, LANDIS J, MADIGAN R, MESSING E, NICKEL J, SANT G, WARREN J, WEIN A, KUSEK J, NYBERG L and FOSTER H (2018) A RANDOMIZED CONTROLLED TRIAL OF INTRAVESICAL BACILLUS CALMETTE-GUERIN FOR TREATMENT REFRACTORY INTERSTITIAL CYSTITISJournal of Urology, VOL. 173, NO. 4, (1186-1191), Online publication date: 1-Apr-2005.SIRINIAN E, AZEVEDO K and PAYNE C (2018) CORRELATION BETWEEN 2 INTERSTITIAL CYSTITIS SYMPTOM INSTRUMENTSJournal of Urology, VOL. 173, NO. 3, (835-840), Online publication date: 1-Mar-2005.SOUCY F and GRÉGOIRE M (2018) EFFICACY OF PREDNISONE FOR SEVERE REFRACTORY ULCERATIVE INTERSTITIAL CYSTITISJournal of Urology, VOL. 173, NO. 3, (841-843), Online publication date: 1-Mar-2005.LOKESHWAR V, SELZER M, CERWINKA W, GOMEZ M, KESTER R, BEJANY D and GOUSSE A (2018) URINARY URONATE AND SULFATED GLYCOSAMINOGLYCAN LEVELS: MARKERS FOR INTERSTITIAL CYSTITIS SEVERITYJournal of Urology, VOL. 174, NO. 1, (344-349), Online publication date: 1-Jul-2005.ERICKSON D, KUNSELMAN A, BENTLEY C, PETERS K, ROVNER E, DEMERS L and TOMASZEWSKI J (2018) IS URINE METHYLHISTAMINE A USEFUL MARKER FOR INTERSTITIAL CYSTITIS?Journal of Urology, VOL. 172, NO. 6 Part 1, (2256-2260), Online publication date: 1-Dec-2004.SANT G, PROPERT K, HANNO P, BURKS D, CULKIN D, DIOKNO A, HARDY C, LANDIS J, MAYER R, MADIGAN R, MESSING E, PETERS K, THEOHARIDES T, WARREN J, WEIN A, STEERS W, KUSEK J and NYBERG L (2018) A Pilot Clinical Trial of Oral Pentosan Polysulfate And Oral Hydroxyzine in Patients With Interstitial CystitisJournal of Urology, VOL. 170, NO. 3, (810-815), Online publication date: 1-Sep-2003.ERICKSON D, XIE S, BHAVANANDAN V, WHEELER M, HURST R, DEMERS L, KUSHNER L and KEAY S (2018) A Comparison of Multiple Urine Markers for Interstitial CystitisJournal of Urology, VOL. 167, NO. 6, (2461-2469), Online publication date: 1-Jun-2002.ERICKSON D, MORGAN K, ORDILLE S, KEAY S and XIE S (2018) NONBLADDER RELATED SYMPTOMS IN PATIENTS WITH INTERSTITIAL CYSTITISJournal of Urology, VOL. 166, NO. 2, (557-562), Online publication date: 1-Aug-2001. Volume 159Issue 3March 1998Page: 1085-1090 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information JAMES E. GOIN More articles by this author DAVID OLALEYE More articles by this author KENNETH M. PETERS More articles by this author BRUCE STEINERT More articles by this author KATHY HABICHT More articles by this author GORDON WYNANT More articles by this author Expand All Advertisement PDF DownloadLoading ...