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Microbiological transformation of prostaglandins

1974; Elsevier BV; Volume: 348; Issue: 2 Linguagem: Inglês

10.1016/0005-2760(74)90237-9

1879-145X

W.J. Marsheck, M. Miyano,

Microbial Metabolic Engineering and Bioproduction

Flavobacterium sp. NRRL B-5641 was found to reduce the 15-ketone of (± )-Δ8(12)-15-dehydroprostaglandin E1 to produce a cis racemic mixture of Δ8(12)-prostaglandin E1 and 11,15-epi-Δ8(12)-prostaglandin E1. The efficiency of the conversion is dependent upon the fermentation medium used and the method of preparation of the inoculum. Pseudomonas sp. NRRL B-3875 reduced (±)-Δ8(12)-15-dehydroprostaglandin E1 to give optically active 11-epi-Δ8(12)-prostaglandin E1 in good yield. Optically active 15-epi-Δ8(12)-prostaglandin E1 was isolated when Flavobacterium sp. NRRL B-3874 or Arthrobacter sp. NRRL 3-3873 reduced (±)-Δ8(12)-15-dehydroprostaglandin E1. The reduction of the 15-ketone or the 13, 14-double bond of (±)-Δ8(12)-15-dehydroprostaglandin E1 was found to be a reaction produced by many bacteria.