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Pharmacology and therapeutic use of antihistamines

1976; Oxford University Press; Volume: 33; Issue: 11 Linguagem: Inglês

10.1093/ajhp/33.11.1200

1535-2900

Vincent J. Cirillo, Kenneth F. Tempero,

Food Allergy and Anaphylaxis Research

The classes of antihistaminic agents, their pharmacology and therapeutic uses, adverse effects, drug interactions, toxic overdoses and abuse are reviewed. It is concluded that antihistamines are valuable drugs for treating a number of conditions and diseases (e.g. allergic rhinitis, motion sickness and parkinsonism), but proof of efficacy has not been established for the treatment of cardiac arrhythmias, peptic ulcers, insomnia and headaches. Because responses to antihistamines may vary, titration of each patient's dose is recommended.