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Inhibition of Transport Processes of Intestinal Segments Following Augmentation Enterocystoplasty in Rats

1996; Lippincott Williams & Wilkins; Volume: 156; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(01)65556-3

1527-3792

Arthur L. Burnett, Mark Donowitz, Fray F. Marshall,

Bladder and Urothelial Cancer Treatments

No AccessJournal of UrologyInvestigative Urology1 Nov 1996Inhibition of Transport Processes of Intestinal Segments Following Augmentation Enterocystoplasty in Rats Arthur L. Burnett, Mark Donowitz, and Fray F. Marshall Arthur L. BurnettArthur L. Burnett More articles by this author , Mark DonowitzMark Donowitz More articles by this author , and Fray F. MarshallFray F. Marshall More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65556-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Sodium and chloride transport was measured by using the Using chamber-voltage clamp technique to evaluate alterations occurring in ileal segments interposed in the urinary tract in a rat enterocystoplasty model. Materials and Methods: In adult male Sprague-Dawley rats which had undergone augmentation ileocystoplasties 3 months earlier, intestinal segments were explanted from the neobladders and native ileal segments were removed separately for electrolyte transport and morphometric analysis. Results: Basal ileal active sodium and chloride absorption and cyclic nucleotide-induced chloride secretion were attenuated in transplanted ileum in contrast to control tissue. Morphologically, there was villus epithelial hyperplasia, crypt hyperplasia and chronic inflammation in transplanted segments, but villus height:crypt length ratios were unchanged. Conclusions: Pathophysiologic derangements in intestinal segments interposed in the urinary tract include inhibition of sodium and chloride transport processes and mucosal hyperplasia. 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Link, Google Scholar Departments of Urology and Gastroenterology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited bySAKAI Y, FUJISAWA M, NAKANO Y, MIYAZAKI S, ARAKAWA S and KAMIDONO S (2018) BACTERIAL ADHERENCE IN A RAT BLADDER AUGMENTATION MODEL: : ILEOCYSTOPLASTY VERSUS COLOCYSTOPLASTYJournal of Urology, VOL. 164, NO. 6, (2104-2107), Online publication date: 1-Dec-2000.NAKANO Y, FUJISAWA M, MATSUI T, ARAKAWA S and KAMIDONO S (2018) THE SIGNIFICANCE OF THE DIFFERENCE IN BACTERIAL ADHERENCE BETWEEN BLADDER AND ILEUM USING RAT ILEAL AUGMENTED BLADDERJournal of Urology, VOL. 162, NO. 1, (243-247), Online publication date: 1-Jul-1999.Di Tonno F, Fabris C, Mazzon E, Lavelli D and Milanesi C (2018) Ultrastructural Mucosal Appearance in the Ileal NeobladderJournal of Urology, VOL. 159, NO. 2S, (620-621), Online publication date: 1-Feb-1998. Volume 156Issue 5November 1996Page: 1872-1875 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Arthur L. Burnett More articles by this author Mark Donowitz More articles by this author Fray F. Marshall More articles by this author Expand All Advertisement PDF downloadLoading ...