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QUALITY OF LIFE AFTER SALVAGE CRYOTHERAPY: THE IMPACT OF TREATMENT PARAMETERS

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(05)68569-2

1527-3792

Paul Perrotte, Mark S. Litwin, Edward J. McGuire, SHELLIE M. SCOTT, Andrew C. von Eschenbach, Louis L. Pisters,

Healthcare and Venom Research

No AccessJournal of UrologyClinical Urology: Original Articles1 Aug 1999QUALITY OF LIFE AFTER SALVAGE CRYOTHERAPY: THE IMPACT OF TREATMENT PARAMETERS PAUL PERROTTE, MARK S. LITWIN, EDWARD J. McGUIRE, SHELLIE M. SCOTT, ANDREW C. VON ESCHENBACH, and LOUIS L. PISTERS PAUL PERROTTEPAUL PERROTTE , MARK S. LITWINMARK S. LITWIN , EDWARD J. McGUIREEDWARD J. McGUIRE , SHELLIE M. SCOTTSHELLIE M. SCOTT , ANDREW C. VON ESCHENBACHANDREW C. VON ESCHENBACH , and LOUIS L. PISTERSLOUIS L. PISTERS View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68569-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Cryotherapy has emerged as a promising salvage therapy option for treatment of locally recurrent prostate cancer after initial therapy. In this retrospective study we evaluate patient quality of life after salvage cryotherapy and correlate complications impairing quality of life with specific cryotherapy treatment parameters. Materials and Methods: A modified UCLA Prostate Cancer Index measuring health related quality of life was sent to 150 patients who underwent salvage cryotherapy between July 1992 and April 1995. We evaluated the relationships among incontinence, pain, impotence, sloughing of tissue and problematic voiding symptoms, and cryotherapy treatment parameters, including use of a urethral warming catheter, number of cryotherapy probes and number of freeze-thaw cycles. We also evaluated patient overall degree of satisfaction with the procedure. Results: Of 150 surveys 112 (74%) were returned. Mean followup was 16.7 months (range 0.5 to 31.5). Treatment without an effective urethral warming catheter was highly associated with urinary incontinence (p <0.003), perineal pain (p <0.001), tissue sloughing (p <0.003) and American Urological Association symptom score greater than 20 (p <0.004). Impotence was higher in the double freeze-thaw cycle group (p <0.05). Overall satisfaction with cryotherapy was 33%. Conclusions: Quality of life may be compromised by urinary incontinence, impotence, tissue sloughing, problematic voiding symptoms and/or perineal pain in a substantial number of patients following salvage cryotherapy. Effective urethral warming is essential in reducing complications and maximizing quality of life. Salvage cryotherapy does not appear to offer any quality of life advantages compared to salvage prostatectomy. References 1 : Critical evaluation of salvage surgery for radio-recurrent/resistant prostate cancer. J. Urol.1995; 154: 1103. 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Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas 77030.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byNg C, Moussa M, Downey D and Chin J (2018) Salvage Cryoablation of the Prostate: Followup and Analysis of Predictive Factors for OutcomeJournal of Urology, VOL. 178, NO. 4, (1253-1257), Online publication date: 1-Oct-2007.TOUMA N, IZAWA J and CHIN J (2018) CURRENT STATUS OF LOCAL SALVAGE THERAPIES FOLLOWING RADIATION FAILURE FOR PROSTATE CANCERJournal of Urology, VOL. 173, NO. 2, (373-379), Online publication date: 1-Feb-2005.WESTNEY O, BEVAN-THOMAS R, PALMER J, CESPEDES R and McGUIRE E (2018) TRANSURETHRAL COLLAGEN INJECTIONS FOR MALE INTRINSIC SPHINCTER DEFICIENCY: THE UNIVERSITY OF TEXAS-HOUSTON EXPERIENCEJournal of Urology, VOL. 174, NO. 3, (994-997), Online publication date: 1-Sep-2005.SHERAR M, GERTNER M, YUE C, O’MALLEY M, TOI A, GLADMAN A, DAVIDSON S and TRACHTENBERG J (2018) INTERSTITIAL MICROWAVE THERMAL THERAPY FOR PROSTATE CANCER: METHOD OF TREATMENT AND RESULTS OF A PHASE I/II TRIALJournal of Urology, VOL. 166, NO. 5, (1707-1714), Online publication date: 1-Nov-2001.IZAWA J, AJAM K, McGUIRE E, SCOTT S, von ESCHENBACH A, SKIBBER J and PISTERS L (2018) MAJOR SURGERY TO MANAGE DEFINITIVELY SEVERE COMPLICATIONS OF SALVAGE CRYOTHERAPY FOR PROSTATE CANCERJournal of Urology, VOL. 164, NO. 6, (1978-1981), Online publication date: 1-Dec-2000.MOUL J (2018) PROSTATE SPECIFIC ANTIGEN ONLY PROGRESSION OF PROSTATE CANCERJournal of Urology, VOL. 163, NO. 6, (1632-1642), Online publication date: 1-Jun-2000. Volume 162Issue 2August 1999Page: 398-402 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information PAUL PERROTTE More articles by this author MARK S. LITWIN More articles by this author EDWARD J. McGUIRE More articles by this author SHELLIE M. SCOTT More articles by this author ANDREW C. VON ESCHENBACH More articles by this author LOUIS L. PISTERS More articles by this author Expand All Advertisement PDF downloadLoading ...