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Elevated hCG as an isolated finding during the second trimester biochemical screen: genetic, ultrasonic, and perinatal significance

1997; Wiley; Volume: 17; Issue: 11 Linguagem: Inglês

10.1002/(sici)1097-0223(199711)17

1097-0223

Moshe Fejgin, Inbal Kedar, Aliza Amiel, T. Ben‐Tovim, Rakefet Chen‐Shtoyerman, Yael Petel, Ron Tepper,

Birth, Development, and Health

Prenatal DiagnosisVolume 17, Issue 11 p. 1027-1031 Original Paper Elevated hCG as an isolated finding during the second trimester biochemical screen: genetic, ultrasonic, and perinatal significance Moshe D. Fejgin, Corresponding Author Moshe D. Fejgin Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelGenetic Institute, Meir Hospital, Kfar-Saba, Israel 44281Search for more papers by this authorInbal Kedar, Inbal Kedar Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorAliza Amiel, Aliza Amiel Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorTalma Ben-Tovim, Talma Ben-Tovim Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorRakefet Chen, Rakefet Chen Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorYael Petel, Yael Petel Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorRon Tepper, Ron Tepper Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this author Moshe D. Fejgin, Corresponding Author Moshe D. Fejgin Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelGenetic Institute, Meir Hospital, Kfar-Saba, Israel 44281Search for more papers by this authorInbal Kedar, Inbal Kedar Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorAliza Amiel, Aliza Amiel Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorTalma Ben-Tovim, Talma Ben-Tovim Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorRakefet Chen, Rakefet Chen Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorYael Petel, Yael Petel Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this authorRon Tepper, Ron Tepper Genetic Institute and Ultrasound Unit, Meir General Hospital, Kfar-Saba and Tel Aviv University Medical School, IsraelSearch for more papers by this author First published: 04 December 1998 https://doi.org/10.1002/(SICI)1097-0223(199711)17:11 3.0.CO;2-FCitations: 15AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract This study was undertaken in an attempt to determine the significance of elevated maternal serum human chorionic gonadotropin (MShCG), in the presence of an otherwise normal screen with respect to fetal malformations, chromosomal aberrations, and pregnancy outcome. Targeted ultrasound findings and perinatal outcome of 298 women in whom serum hCG was ≥2·5 MOM and who were screen-negative for Down syndrome (the study group) were compared with a control group of 229 women in whom serum hCG as well as the other parameters were within the normal range. Genetic amniocentesis was performed in 125 women from the study group. Ultrasonically detected malformations were significantly more frequent among the study group (12 vs. 1, P=0·01). Pregnancy complications were similar in the two groups, with the exception of pre-eclampsia–toxaemia, which was significantly more frequent in the study group (5 vs. 0, P=0·02). There was one case of an abnormal karyotype (47,XXY). Although genetic amniocentesis does not appear warranted, isolated elevated MShCG levels during the second trimester screening was associated with an increased risk of fetal anomalies detected by ultrasound and of toxaemia of pregnancy. © 1997 John Wiley & Sons, Ltd. References Barnes-Kedar, I., Amiel, A., Maor, O., Fejgin, M. (1993). Elevated human chorionic gonadotropin levels in pregnancies with sex chromosome abnormalities, Am. J. Med. Genet., 45, 356–357. Benn, P. A., Horne, D., Briganti, S., Rodis, J. F., Clive, J. M. (1996). Elevated second trimester maternal serum hCG alone or in combination with elevated alpha-fetoprotein, Obstet. Gynecol., 87, 217–222. Crossley, J. A., Aitken, D. A., Connor, J. M. (1991). 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