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BIBTEX RIS

The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

2022; UNIVERSIDADE DE SÃO PAULO; Volume: 64; Linguagem: Inglês

10.1590/s1678-9946202264064

ISSN

1678-9946

Autores

Patrícia Azevedo Soares Cordeiro, Tatiane Assone, Gabriela Prates, Márcia Regina Martinez Tedeschi, Luiz Augusto Marcondes Fonseca, Jorge Casseb,

Tópico(s)

RNA regulation and disease

Resumo

Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.

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