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Sociodemographic and clinical factors associated with poor COVID-19 outcomes in patients with rheumatic diseases: data from the SAR-COVID Registry

2022; Springer Science+Business Media; Volume: 42; Issue: 2 Linguagem: Inglês

10.1007/s10067-022-06393-8

1434-9949

C. A. Isnardi, Karen Roberts, Verónica Saurit, Ingrid Petkovic, Roberto Miguel Báez, Rosana Quintana, Yohana Tissera, Sofía Ornella, Maria Eugenia D’Angelo Exeni, Cecilia Pisoni, Vanessa Viviana Castro Coello, Guillermo Berbotto, María Jezabel Haye Salinas, E. Velozo, Alvaro Andres Reyes Torres, Romina Tanten, Marcos David Zelaya, Carla Gobbi, Carla Gimena Alonso, María de los Ángeles Severina, Florencia Vivero, Alba Paula, Adriana Karina Cogo, Gelsomina Alle, Mariana Pera, Romina Nieto, M. Cosatti, Cecilia Asnal, Dora Pereira, Juan Alejandro Albiero, V. Savio, F. Maldonado, María Julieta Gamba, Noelia Germán, Andrea Baños, Josefina Gallino Yanzi, M. S. Gálvez Elkin, Julieta Silvana Morbiducci, María Victoria Martiré, Hernán Maldonado Ficco, Maria Marcela Schmid, Jaime A. Villafañe Torres, María de los Ángeles Correa, María Alejandra Medina, María Alejandra Cusa, Julia Scafati, Santiago Eduardo Agüero, Nicolás Martín Lloves Schenone, Enrique R. Soriano, César Graf, Bernardo A. Pons‐Estel, Gimena Gómez, M. Landi, María Celina de la Vega, Guillermo J. Pons‐Estel, Verónica Saurit, Ingrid Petkovic, Roberto Miguel Báez, Guillermo J. Pons‐Estel, Yohana Tissera, Sofía Ornella, Ida Elena Exeni, Cecilia Pisoni, Vanessa Castro Coello, Guillermo Berbotto, María Jezabel Haye Salinas, E. Velozo, Alvaro Andres Reyes Torres, Romina Tanten, Marcos David Zelaya, Carla Gobbi, Carla Gimena Alonso, María de los Ángeles Severina, Florencia Vivero, Alba Paula, Karina Cogo, Gelsomina Alle, Mariana Pera, Romina Nieto, M. Cosatti, Cecilia Asnal, Dora Pereira, Juan Alejandro Albiero, V. Savio, F. Maldonado, María Julieta Gamba, Noelia Germán, Andrea Baños, Josefina Gallino Yanzi, M. S. Gálvez Elkin, Julieta Silvana Morbiducci, María Victoria Martiré, Hernán Maldonado Ficco, María Marcela Schmid, Jaime Villafane, María de los Ángeles Correa, María Alejandra Medina, María Alejandra Cusa, Julia Scafati, Santiago Eduardo Agüero, Nicolás Martín Lloves Schenone, Ivana Romina Rojas Tessel, Rodolfo Pérez Alamino, Aixa Lucia Mercé, María Celina de la Vega, Verónica Bellomio, Carlevaris Leandro, Jonatan Marcos Mareco, Rosa María Figueroa, María Alicia Lázaro, Mercedes García, María Isabel Quaglia, Luciana González Lucero, Lorena Takashima, Marina Laura Werner, Fabián Risueño, Natalia Lili Cucchiaro, Ana M. Bertoli, Gisela Pendon, Gustavo Fabián Rodriguez Gil, Pablo Finucci Curi, Laura Raiti, Andrea Belen Gomez Vara, Luciana Casalla, Eugenia Picco, Leila Mariana Muñoz, María Elena Calvo, Diana Marcela Castrillón, Catalina Gómez, Mercedes Cecilia Córdoba, Camila Rosario Reyes Gómez, Brian Manases Roldán, C. Amitrano, Carla Matellan, Sidney Soares de Souza, Florencia Rodríguez, Carolina Aeschlimann, Vicente Juárez, César Graf, Marianela Eliana Mauri, Cecilia Romeo, Elisa Novatti, María Natalia Tamborenea, Raúl Paniego, Malena Viola, Vanesa Cosentino, Sandra Petruzzeli, Zaida Noemi Bedran, Sebastián Moyano, Tatiana Barbich, Silvana Conti, Carla Maldini, Maria Daniela Alonso, María Victoria Borgia, Ana Carolina Ledesma, María Luz Centeno Martín, Boris Kisluk, Susana Pineda, Natalia Herscovich, Leticia Ibáñez Zurlo, Elda Rossella Tralice, Dora Lia Vasquez, Natalia Morales, Mónica Patricia Díaz, Hernan Ariel Molina Merino, Rosana Gallo, Jessica Luciana Tomas, Anibal Alba, Graciela Lara Gómez, Gisela Subils, A. Testi, Gisele Verna, Maria Eugenia Bedoya, Victor Yohena, Debora Guaglionone, J. Rebak, Maria Mercedes Croce, Carolina Dieguez, Mara Guinsburg, Santiago Catalán Pellet, Pablo Maid, Sabrina Porta, Norberto Javier Quagliato, Sabrina Solange de la Vega Fernandez, Emilio Buschiazzo, José Luis Velasco Zamora, María Silvina Pérez Rodríguez, Federico Martin Paniego, Maria Lourdes Mamani Ortega, Graciela Vanesa Betancur, Rosa Serrano, Maria Sol Castaños Menescardi, Cinthya Retamozo, Cecilia Goizueta, A. Quinteros, Fernanda Abadie, Ignacio Carrillo, Fernanda Guzzanti,

Dermatological and COVID-19 studies

This study aims to describe the course and to identify poor prognostic factors of SARS-CoV-2 infection in patients with rheumatic diseases.Patients ≥ 18 years of age, with a rheumatic disease, who had confirmed SARS-CoV-2 infection were consecutively included by major rheumatology centers from Argentina, in the national, observational SAR-COVID registry between August 13, 2020 and July 31, 2021. Hospitalization, oxygen requirement, and death were considered poor COVID-19 outcomes.A total of 1915 patients were included. The most frequent rheumatic diseases were rheumatoid arthritis (42%) and systemic lupus erythematosus (16%). Comorbidities were reported in half of them (48%). Symptoms were reported by 95% of the patients, 28% were hospitalized, 8% were admitted to the intensive care unit (ICU), and 4% died due to COVID-19. During hospitalization, 9% required non-invasive mechanical ventilation (NIMV) or high flow oxygen devices and 17% invasive mechanical ventilation (IMV). In multivariate analysis models, using poor COVID-19 outcomes as dependent variables, older age, male gender, higher disease activity, treatment with glucocorticoids or rituximab, and the presence of at least one comorbidity and a greater number of them were associated with worse prognosis. In addition, patients with public health insurance and Mestizos were more likely to require hospitalization.In addition to the known poor prognostic factors, in this cohort of patients with rheumatic diseases, high disease activity, and treatment with glucocorticoids and rituximab were associated with worse COVID-19 outcomes. Furthermore, patients with public health insurance and Mestizos were 44% and 39% more likely to be hospitalized, respectively.This study has been registered in ClinicalTrials.gov under the number NCT04568421. Key Points • High disease activity, and treatment with glucocorticoids and rituximab were associated with poor COVID-19 outcome in patients with rheumatic diseases. • Some socioeconomic factors related to social inequality, including non-Caucasian ethnicity and public health insurance, were associated with hospitalization due to COVID-19.