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Dapsone in the Treatment of Presumed Brown Recluse Spider Bite of the Eyelid

1985; Volume: 16; Issue: 2 Linguagem: Inglês

10.3928/1542-8877-19850201-14

2325-8179

Ralph E. Wesley, W H Ballinger, L Ward Close, Allyn M Lay,

Drug-Induced Adverse Reactions

ABSTRACT Brown recluse spider bites occur commonly in the Southern United States but eyelid bites are rare. Management of eyelid bites is difficult because the initial spider bite is frequently unnoticed, surgical and medical treatments are ineffective, and even a small area of necrosis affects the appearance and function of the eyelid. Dapsone (4,4,′ diaminodiphenyl sulfone), which inhibits the infiltration of polymorphonuclear leukocytes necessary to mediate the gangrenous skin destruction, has been reported to be effective in treatment of the brown recluse spider bite in both experimental and clinical usage. We report herein a presumed eyelid brown recluse spider bite in which inflammation responded dramatically to treatment with oral Dapsone. Earlier treatment may have prevented eyelid margin necrosis that required reconstruction.