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Perinatal Depressive Symptoms and Viral Non-suppression Among a Prospective Cohort of Pregnant Women Living with HIV in Nigeria, Kenya, Uganda, and Tanzania

2022; Springer Science+Business Media; Volume: 27; Issue: 3 Linguagem: Inglês

10.1007/s10461-022-03810-6

1573-3254

Tessa Concepcion, Jennifer Velloza, Christopher G. Kemp, Amritha Bhat, Ian M. Bennett, Deepa Rao, Christina S. Polyak, Julie A. Ake, Allahna Esber, Nicole Dear, Jonah Maswai, John Owuoth, Valentine Sing’oei, Emmanuel Bahemana, Michael Iroezindu, Hannah Kibuuka, Pamela Y. Collins,

Adolescent Sexual and Reproductive Health

Abstract Depression is common during pregnancy and is associated with reduced adherence to HIV-related care, though little is known about perinatal trajectories of depression and viral suppression among women living with HIV (WLHV) in sub-Saharan Africa. We sought to assess any association between perinatal depressive symptoms and viral non-suppression among WLWH. Depressive symptomatology and viral load data were collected every 6 months from WLWH enrolled in the African Cohort Study (AFRICOS; January 2013–February 2020). Generalized estimating equations modeled associations between depressive symptoms [Center for Epidemiological Studies Depression (CES-D) ≥ 16] and viral non-suppression. Of 1722 WLWH, 248 (14.4%) had at least one pregnancy (291 total) and for 61 pregnancies (21.0%), women reported depressive symptoms (13.4% pre-conception, 7.6% pregnancy, 5.5% one-year postpartum). Depressive symptomatology was associated with increased odds of viral non-suppression (aOR 2.2; 95% CI 1.2–4.0, p = 0.011). Identification and treatment of depression among women with HIV may improve HIV outcomes for mothers.