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Association of Antibodies to Prevotella copri in Anti–Cyclic Citrullinated Peptide‐Positive Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis

2022; Wiley; Volume: 75; Issue: 4 Linguagem: Inglês

10.1002/art.42370

2326-5205

Jennifer Seifert, Elizabeth A. Bemis, Kristina Ramsden, Cassidy Lowell, Kristen J. Polinski, Marie L. Feser, Chelsie Fleischer, M. Kristen Demoruelle, Jane H. Buckner, Peter K. Gregersen, Richard M. Keating, Ted R. Mikuls, James R. O’Dell, Michael H. Weisman, Kevin D. Deane, Jill M. Norris, Allen C. Steere, V. Michael Holers,

Clostridium difficile and Clostridium perfringens research

Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti-P copri (anti-Pc) antibody responses in our participant cohorts and to determine when in the natural history of RA such responses develop.