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Effects of dietary chitosan on the growth, health status and disease resistance of golden pompano (Trachinotus ovatus)

2022; Elsevier BV; Volume: 300; Linguagem: Inglês

10.1016/j.carbpol.2022.120237

1879-1344

Wei Yu, Yukai Yang, Haimin Chen, Qicun Zhou, Yanwa Zhang, Xiaolin Huang, Zhong Huang, Tao Li, Chuanpeng Zhou, Zhenhua Ma, Qiaer Wu, Heizhao Lin,

Aquatic life and conservation

The effects of dietary chitosan (0, 2, 4, 6, 8 and 10 g/kg) on the growth, health condition and disease resistance of golden pompano Trachinotus ovatus were evaluated. Dietary chitosan significantly enhanced weight gain, with the highest observed in fish fed the 6 g/kg chitosan diet. This chitosan level significantly promoted gut health by increasing villus length, lipase and protease activities and intestinal barrier-related genes expression. Meanwhile, dietary 6 g/kg chitosan improved the inflammatory response and anti-oxidative capacity of fish by regulating the expression of genes involved in NF-κB pathway and Nrf2 pathway, respectively. Furthermore, after challenge with Vibrio harveyi for 2 weeks, the survival rate increased significantly when dietary chitosan level was 6 g/kg. Overall, our results indicate that 6 g/kg chitosan is the optimal dose for enhancing growth, health and disease resistance of fish, but excessive chitosan (10 g/kg) weakens its beneficial effects.