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Accessing the Variability of Multicopy Genes in Complex Genomes using Unassembled Next-Generation Sequencing Reads: The Case of Trypanosoma cruzi Multigene Families

2022; American Society for Microbiology; Volume: 13; Issue: 6 Linguagem: Inglês

10.1128/mbio.02319-22

ISSN

2161-2129

Autores

João Luís Reis-Cunha, Anderson Coqueiro dos Santos, Samuel Alexandre Pimenta Carvalho, Larissa Pinheiro Marques, Gabriela F Rodrigues-Luiz, Rodrigo P. Baptista, Laila Viana de Almeida, Nathan Ravi Medeiros Honorato, Francisco Pereira Lobo, Vanêssa Gomes Fraga, Lúcia Maria da Cunha Galvão, Lilian Lacerda Bueno, Ricardo Toshio Fujiwara, Mariana Santos Cardoso, Gustavo Cerqueira, Daniella Castanheira Bartholomeu,

Tópico(s)

Biochemical and Molecular Research

Resumo

Sequences that have several copies in a genome, such as multicopy-gene families, mobile elements, and microsatellites, are among the most challenging genomic segments to study. They are frequently underestimated in genome assemblies, hampering the correct assessment of these important players in genome evolution and adaptation.

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