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Postdiagnosis body fatness, weight change and breast cancer prognosis: Global Cancer Update Program (CUP global) systematic literature review and meta‐analysis

2022; Wiley; Volume: 152; Issue: 4 Linguagem: Inglês

10.1002/ijc.34322

1097-0215

Doris S. M. Chan, Rita Vieira, Leila Abar, Dagfinn Aune, Katia Balducci, Margarita Cariolou, Darren C. Greenwood, Georgios Markozannes, Neesha Nanu, Nerea Becerra‐Tomás, Edward L. Giovannucci, Marc J. Gunter, Alan A. Jackson, Ellen Kampman, Vivien Lund, Kate Allen, Nigel T. Brockton, Helen Croker, Daphne Katsikioti, Deirdre McGinley‐Gieser, Panagiota Mitrou, Martin Wiseman, Amanda J. Cross, Elio Ríboli, Steven K. Clinton, Anne McTiernan, Teresa Norat, Konstantinos K. Tsilidis,

Multiple and Secondary Primary Cancers

Previous evidence on postdiagnosis body fatness and mortality after breast cancer was graded as limited-suggestive. To evaluate the evidence on body mass index (BMI), waist circumference, waist-hip-ratio and weight change in relation to breast cancer prognosis, an updated systematic review was conducted. PubMed and Embase were searched for relevant studies published up to 31 October, 2021. Random-effects meta-analyses were conducted to estimate summary relative risks (RRs). The evidence was judged by an independent Expert Panel using pre-defined grading criteria. One randomized controlled trial and 225 observational studies were reviewed (220 publications). There was strong evidence (likelihood of causality: probable) that higher postdiagnosis BMI was associated with increased all-cause mortality (64 studies, 32 507 deaths), breast cancer-specific mortality (39 studies, 14 106 deaths) and second primary breast cancer (11 studies, 5248 events). The respective summary RRs and 95% confidence intervals per 5 kg/m