Portal de Periódicos da CAPES

K index utility as diagnostic and prognostic biomarker in the assessment of patients with suspected Multiple Sclerosis

2022; Elsevier BV; Volume: 373; Linguagem: Inglês

10.1016/j.jneuroim.2022.577992

1872-8421

Claudia Cutellé, Claudia Balducci, Diletta Cereda, Maria Letizia Fusco, Davide Iacobucci, Jacopo Perugini, Fiammetta Pirro, Rinaldo Brivio, Davide Paolo Bernasconi, Carlo Ferrarese, M. Frigo, Guido Cavaletti,

Peripheral Neuropathies and Disorders

The aim of the present study is to evaluate the composite role of k index in the initial assessment of Multiple Sclerosis (MS) patients and to select useful cut-offs exportable in clinical practice. We analysed CSF/serum samples of 140 patients and followed-up the CIS/MS subgroup for 7 years. Our results suggest κ index as a quantitative diagnostic and prognostic biomarker in MS, significantly associated to baseline lesion load and to successive clinical course. We propose k index ≥106 as a prognostic cut-off to select patients at major risk of relapse, potentially influencing initial therapeutic decisions.