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Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries

2022; Frontiers Media; Volume: 10; Linguagem: Inglês

10.3389/fped.2022.1033125

2296-2360

Xavier Carbonell‐Estrany, Eric A. F. Simões, Louis Bont, Ángela Gentile, Nusrat Homaira, Marcelo Comerlato Scottá, Renato T. Stein, Juan Pablo Torres, Sheikh Jarju, Shobha Broor, Najwa Khuri‐Bulos, D. James Nokes, Patrick K. Munywoki, Quique Bassat, Arun Kumar Sharma, Sudha Basnet, Maria Ahuoiza Garba, Joanne de Jesus-Cornejo, Socorro Lupisan, Marta C. Nunes, M. V. M. Divarathna, John R. Fullarton, Barry Rodgers‐Gray, Ian P. Keary, Mark Donald C. Reñosa, Charl Verwey, David P. Moore, F. Noordeen, S. K. Kabra, Marynéa Silva do Vale, Rolando Paternina-De La Ossa, Cristina Mariño, J. Figueras Aloy, Leonard R. Krilov, Eitan N. Berezin, Heather J. Zar, Krishna Paudel, Marco Aurélio Palazzi Sáfadi, Ghassan Dbaibo, Imane Jroundi, Runa Jha, Rukshan A. M. Rafeek, Rossiclei de Souza Pinheiro, Marianne Bracht, Rohitha Muthugala, Marcello Lanari, Federico Martinón‐Torres, Ian Mitchell, Grace Irimu, Apsara Pandey, Anand Krishnan, Asunción Mejías, Marcela Santos Corrêa da Costa, Shrijana Shrestha, Jeffrey M. Pernica, Felipe Cotrim de Carvalho, Rose Jalang’o, Hafsat Ibrahim, Atana Ewa, Gabriela Ensinck, Rolando Ulloa‐Gutiérrez, Alexandre Lopes Miralha, María Florencia Luciön, Md Zakiul Hassan, Zubair Akhtar, Mohammad Abdul Aleem, Fahmida Chowdhury, Pablo Rojo, Charles Sande, Abednego Musau, Khalequ Zaman, Luiza Helena, Falleiros Arlant, Prakash Ghimire, April Price, Kalpana Upadhyay Subedi, Helena Brenes-Chacón, Doli Goswami, Mohammed Ziaur Rahman, Mohammad Enayet Hossain, Mohammod Jobayer Chisti, Néstor Vain, Audrey Lim, Aaron Chiu, Jesse Papenburg, María Del Valle Juárez, Thamarasi Senaratne, Shiyamalee Arunasalam, Tor A. Strand, Adaeze C. Ayuk, Olufemi Ogunrinde, Lohanna Valeska de Sousa Tavares, Comfort Garba, Bilkisu Ilah Garba, Jeanette Dawa, Michelle Gordon, Eric Osoro, Charles N. Agoti, Bryan O. Nyawanda, Mwanajuma Ngama, Collins Tabu, Joseph L. Mathew, Andrew Cornacchia, Ganesh Kumar, Amita Jain, Mateus Sfoggia Giongo, Bosco Paes,

Pneumonia and Respiratory Infections

The high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce of 24 RSV worldwide experts assessed key needs for RSV prevention in LMICs, including vaccine and newer preventive measures.A global, survey-based study was undertaken in 2021. An online questionnaire was developed following three meetings of the Taskforce panellists wherein factors related to RSV infection, its prevention and management were identified using iterative questioning. Each factor was scored, by non-panellists interested in RSV, on a scale of zero (very-low-relevance) to 100 (very-high-relevance) within two scenarios: (1) Current and (2) Future expectations for RSV management.Ninety questionnaires were completed: 70 by respondents (71.4% physicians; 27.1% researchers/scientists) from 16 LMICs and 20 from nine high-income (HI) countries (90.0% physicians; 5.0% researchers/scientists), as a reference group. Within LMICs, RSV awareness was perceived to be low, and management was not prioritised. Of the 100 factors scored, those related to improved diagnosis particularly access to affordable point-of-care diagnostics, disease burden data generation, clinical and general education, prompt access to new interventions, and engagement with policymakers/payers were identified of paramount importance. There was a strong need for clinical education and local data generation in the lowest economies, whereas upper-middle income countries were more closely aligned with HI countries in terms of current RSV service provision.Seven key actions for improving RSV prevention and management in LMICs are proposed.