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The ubiquitin E3 ligase Parkin regulates neuronal Ca V 1.3 channel functional expression

2022; American Physiological Society; Volume: 128; Issue: 6 Linguagem: Inglês

10.1152/jn.00287.2022

1522-1598

Lizbeth Grimaldo, Alejandro Sandoval, Paz Duran, Liliana Gómez-Flores-Ramos, Ricardo Felix,

Genetic Neurodegenerative Diseases

The increased expression of Ca V 1.3 calcium channels is a crucial feature of Parkinson’s disease (PD) pathophysiology. However, the mechanisms that determine this increase are not yet defined. Parkin, an enzyme of the ubiquitin-proteasome system, is known to interact with neuronal channels promoting their ubiquitin-mediated degradation. Interestingly, Parkin mutations also play a role in PD. Here, the degradation mechanisms of Ca V 1.3 channels and their relationship with the pathophysiology of PD are studied in detail.