Produção Nacional
Revisado por pares
Five-year survival rate and prognostic factors in women with breast cancer treated at a reference hospital in the Brazilian Amazon
2022; Public Library of Science; Volume: 17; Issue: 11 Linguagem: Inglês
10.1371/journal.pone.0277194
ISSN1932-6203
AutoresSoany de Jesus Valente Cruz, Andressa Karoline Pinto de Lima Ribeiro, Maria da Conceição Nascimento Pinheiro, Vânia Cristina Campelo Barroso Carneiro, Laura Maria Tomazi Neves, Saúl Rassy Carneiro,
Tópico(s)Breast Cancer Treatment Studies
ResumoBreast cancer is the most prevalent malignant neoplasm and the leading cause cancer of death among women globally. In Brazil, survival rates vary according to the region and few studies have been conducted on breast cancer survival in less developed areas, such as the Amazon region. The aim of this study was to analyze the five-year survival rate and prognostic factors in women treated for breast cancer in the city of Belém in northern Brazil. A retrospective hospital-based cohort study was conducted (2007–2013). Sociodemographic, clinical/tumor, and treatment variables were obtained from the records at the Ophir Loyola Hospital. Survival analysis involved the Kaplan-Meier statistical method and Cox regression analysis was performed. The significance level was 5% (p <0.05). A total of 1,430 cases were analyzed. Mean survival time was 51.71 (± 17.22) months, with an estimated overall survival of 79.4%. In the multivariate analysis, referral from the public health care system, advanced clinical stage, lymph node involvement and metastasis were associated with worse prognosis and lower survival rate. Radiotherapy and hormone therapy were associated with increased survival. These findings can contribute to the development of regional strategies for early detection of breast cancer, reducing the incidence and mortality rates and increasing survival time.
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