Produção Nacional
Revisado por pares
The Barretos Cancer Hospital Animal Facility: Implementation and Results of a Dedicated Platform for Preclinical Oncology Models
2022; Multidisciplinary Digital Publishing Institute; Volume: 9; Issue: 11 Linguagem: Inglês
10.3390/vetsci9110636
ISSN2306-7381
AutoresSílvia Teixeira, Mayara de Cássia Luzzi, Ana Carolina Baptista Moreno Martin, Terence Duarte, Mônica de Oliveira Leal, Gustavo Ramos Teixeira, Monise Tadin Reis, Carlos Almeida, K. M. O. dos Santos, Matias Eliseo Melendez, Diego da Cunha Silveira Alves da Silva, Priscila Neves Bernécule, Higor Vinicius Lourenço Firmino, Ana Laura Vieira Alves, Denise Peixoto Guimarães, João Vitor Borduqui, Ana Carolina Laus, Bruna Minniti Mançano, Rui Manuel Reis,
Tópico(s)Cancer Genomics and Diagnostics
ResumoThe Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and ApcMin mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
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