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BIBTEX RIS

Nanotechnology as a tool to overcome macromolecules delivery issues

2022; Elsevier BV; Volume: 222; Linguagem: Inglês

10.1016/j.colsurfb.2022.113043

1873-4367

Louise Lacalendola Tundisi, Janaína Artem Ataide, Juliana Souza Ribeiro Costa, D. Coelho, Raquel Bester Liszbinski, André Moreni Lopes, Laura de Oliveira Nascimento, Marcelo Bispo de Jesus, Ângela Faustino Jozala, Carsten Ehrhardt, Priscila Gava Mazzola,

Drug Solubulity and Delivery Systems

Nanocarriers can deliver drugs to specific organs or cells, potentially bridging the gap between a drug's function and its interaction with biological systems such as human physiology. The untapped potential of nanotechnology stems from its ability to manipulate materials, allowing control over physical and chemical properties and overcoming drug-related problems, e.g., poor solubility or poor bioavailability. For example, most protein drugs are administered parenterally, each with challenges and peculiarities. Some problems faced by bioengineered macromolecule drugs leading to poor bioavailability are short biological half-life, large size and high molecular weight, low permeability through biological membranes, and structural instability. Nanotechnology emerges as a promising strategy to overcome these problems. Nevertheless, the delivery system should be carefully chosen considering loading efficiency, physicochemical properties, production conditions, toxicity, and regulations. Moving from the bench to the bedside is still one of the major bottlenecks in nanomedicine, and toxicological issues are the greatest challenges to overcome. This review provides an overview of biotech drug delivery approaches, associated nanotechnology novelty, toxicological issues, and regulations.