Produção Nacional
Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol
2022; Hindawi Publishing Corporation; Volume: 2022; Linguagem: Inglês
10.1155/2022/8002766
ISSN2633-4690
AutoresMayara Ladeira Coêlho, Muhammad Torequl Islam, George Laylson da Silva Oliveira, Marcus Vinícius Oliveira Barros de Alencar, José Víctor De Oliveira Santos, Antonielly Campinho dos Reis, Ana Maria Oliveira Ferreira da Mata, Márcia Fernanda Correia Jardim Paz, Anca Oana Docea, Daniela Călina, Javad Sharifi‐Rad, Ana Amélia de Carvalho Melo‐Cavalcante,
Tópico(s)Plant chemical constituents analysis
ResumoThe therapeutic potential of medicinal plants is noted because of the presence of varieties of biochemicals. The monoterpenes, like nerol, estragole, and 3,7-dimethyl-1-octanol, have been reported for antimicrobial, antifungal, anthelmintic, and antioxidant activities. This study evaluated the toxic, cytotoxic, and oxidant/antioxidant effects of these compounds by several in vitro (DPPH and ABTS radical scavenging, and ferric reducing potential), ex vivo (hemolysis), and in vivo (Artemia Salina and Saccharomyces cerevisiae) assays. Results suggest that estragole and 3,7-dimethyl-1-octanol at 31.25–500 μg/mL did not exhibit significant cytotoxic effects in the A. Salina and hemolysis tests. Nerol showed significant cytotoxic effects on these test systems at all test concentrations. The monoterpenes showed radical (ABTS•+ and DPPH•) scavenging capacities in a concentration-dependent manner in vitro tests. However, they did not oxidize the genetic material of S. cerevisiae (SODWT, Sod1Δ, Sod2Δ, Sod1/Sod2Δ, Cat1Δ, and Cat1Δ/Sod1Δ) lines. Among the three monoterpenes, nerol may be a good candidate for antioxidant and anti-tumor therapies.
Referência(s)