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Computed tomographic airway morphology after targeted lung denervation treatment in COPD

2022; Elsevier BV; Volume: 206; Linguagem: Inglês

10.1016/j.rmed.2022.107059

1532-3064

Jorine E. Hartman, Felix J.F. Herth, Pallav L. Shah, Christophe Pison, Arschang Valipour, Dirk‐Jan Slebos, Arschang Valipour, Christine Abele, Irene Firlinger, Kiran Kothakuzhakal, Marina Duller, Bernd Lamprecht, Roland Kropfmueller, Kornelia Holzmann, Sandra Rathmeier, Ralf‐Harto Hübner, Leonore Erdmann, Bettina Temmesfeld‐Wollbrück, Christoph Ruwwe Glösenkamp, Wolfgang Gesierich, Frank Reichenberger, Christa Niehaus, Felix J.F. Herth, Ralf Eberhardt, Daniela Gompelmann, B. Rump, Kaid Darwiche, Stephan Eisenmann, Ulrike Kaiser, Birte Schwarz, Ulrike Sampel, Christian Schumann, Robert A. Kaiser, Christian Schumann, Dirk Skowasch, Sabine Ring, Christophe Pison, Amandine Briault, François Arbib, Marie Jondot, T. Pérez, C. Fournier, Régis Matran, Michèle Catto, Nathalie Bautin, Virginie de Broucker, Marie Willemin, Anne Prévötat, Ludivine Wemeau, Alice Gicquello, Morgane Foulon, Hasna Camara, Gaëtan Deslée, H. Vallerand, Sandra Dury, Delphine Gras, Margaux Bonnaire-Verdier, Romain Kessler, Sandrine Hirschi, Michele Porzio, Tristan Dégot, Mathieu Canuet, Armelle Schuller, J Stauder, Sahra Ali Azouaou, Armelle Marceau, Hervé Mal, Yolande Costa, Pallav L. Shah, Justin Garner, Karthi Srikanthan, Cielito Caneja, John Thornton, Dirk‐Jan Slebos, Nick ten Hacken, Jorine E. Hartman, Karin Klooster, Sonja W.S. Augustijn, Peter I. Bonta, Jouke T. Annema, Marianne van de Pol, Annika W.M. Goorsenberg,

Inhalation and Respiratory Drug Delivery

This post-hoc analysis of the AIRFLOW-2 trial investigated the changes in airway CT-parameters after targeted lung denervation (TLD) and whether these changes are associated with treatment response. In the treatment group (n = 32), an improvement in air trapping was significantly associated with an improvement in residual volume (RV). Furthermore, improvements in Pi10 and airway lumen were significantly associated with an improvement in both RV and FEV1. Our results could suggest that when improving airway characteristics like decreasing airway wall thickness and increasing the airway lumen, this leads to less air trapping and an improvement in clinical outcomes.