Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines
2022; BioMed Central; Volume: 14; Issue: 1 Linguagem: Inglês
10.1186/s13073-022-01137-4
ISSN1756-994X
AutoresGerard Godoy‐Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle‐Fabregat, Ricardo Martins-Ferreira, Anna G. Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez‐Gallo, Ricard Ferrer, Juan Carlos Ruiz‐Rodríguez, Javier Rodríguez‐Ubreva, Roser Vento‐Tormo, Esteban Ballestar,
Tópico(s)Immune cells in cancer
ResumoCOVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients.
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