Artigo Acesso aberto Revisado por pares

Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines

2022; BioMed Central; Volume: 14; Issue: 1 Linguagem: Inglês

10.1186/s13073-022-01137-4

ISSN

1756-994X

Autores

Gerard Godoy‐Tena, Anis Barmada, Octavio Morante-Palacios, Carlos de la Calle‐Fabregat, Ricardo Martins-Ferreira, Anna G. Ferreté-Bonastre, Laura Ciudad, Adolfo Ruiz-Sanmartín, Mónica Martínez‐Gallo, Ricard Ferrer, Juan Carlos Ruiz‐Rodríguez, Javier Rodríguez‐Ubreva, Roser Vento‐Tormo, Esteban Ballestar,

Tópico(s)

Immune cells in cancer

Resumo

COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially monocytes. However, little is known about the epigenetic alterations that occur in these cells during hyperinflammatory responses in severe COVID-19 patients.

Referência(s)