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Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

2022; Nature Portfolio; Volume: 12; Issue: 1 Linguagem: Inglês

10.1038/s41598-022-24409-w

2045-2322

Christine Durier, Läétitia Ninove, M. Lefèbvre, Anne Radenne, Corinne Desaint, Jacques Ropers, Rebecca Bauer, Saïd Lebbah, Diane Carette, Marie Lachâtre, Anne-Sophie Lecompte, Dominique Deplanque, Élisabeth Botelho-Nevers, Anne Conrad, Bertrand Dussol, Z. Maakaroun-Vermesse, Giovanna Melica, Jean–François Nicolas, Renaud Verdon, Jacques Kiladjian, Paul Loubet, Catherine Schmidt‐Mutter, Christian Dualé, Séverine Ansart, Stéphane Priet, Axel Levier, Diana Molino, Louis-Victorien Vieillard, Béatrice Parfait, Jean‐Daniel Lelièvre, Éric Tartour, Xavier de Lamballerie, Odile Launay, Gilbert Mchantaf, Berthe‐Marie Imbert‐Marcille, Samantha Montagne, Bijan Ghaleh-Marzban, Alexandra Traverse-Gléhen, Denis Vivien, Bruno Cassinat, Alexandre Evrard, Catherine Metzger, Jean‐Marc Lessinger, Michel Billing, Marc Berger, Christophe Leroyer, Éric Tartour, Victor Appay, Frédéric Batteux, Christophe Combadière, Guy Gorochov, Stéphane Paul, Sylvie van der Werf, Christiane S. Eberhardt, Claire‐Anne Siegrist, Michel Cogné, Isabelle Pellegrin, Marc Éloit, Emmanuelle Netzer, Martine Resch, Marine Saouzanet, Laurence Meyer, Marion Bonneton, Raphaëlle Tardieu, Soizic Le Mestre, Solange Jancrey-Laval, Ventzislava Petrov–Sanchez, Éric Rosenthal, Yazdan Yazdanpanah, Daniel Olive, Raphaëlle Tardieu, Ventzislava Petrov–Sanchez, Amel Bouakane, Véronique Rieux, Claire Madelaine, Soizic Lemestre, Alpha Diallo, Solange Lancrey-javal, Laurence Meyer, Emmanuelle Netzer, Marine Saouzanet, Florent Valour, Bertrand Dussol, Giovanna Melica, Gilbert Mchantaf, Michael Hisbergues, Frédérique Bertholon, Vinca Icard, Annachiara De Sandre‐Giovannoli, Bijan Ghaleh-Marzban, Victor Appay, Frédéric Batteux, Christophe Combadière, Guy Gorochov, Stéphane Paul, Sylvie van der Werf, Christiane S. Eberhardt, Claire‐Anne Siegrist, Michel Cogné, Margot Dropy, Fatiha Bouchama, Mehdi Thamri, Saïd Lebbah, Marion Bonneton, Shorheh Azimi, Béatrice Parfait, Victor Appay, Frédéric Batteux, Christophe Combadière, Guy Gorochov, Stéphane Paul, Sylvie van der Werf, Claire‐Anne Siegrist, Michel Cogné, Florent Valour,

Animal Virus Infections Studies

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65-84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.