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The effect of orthodontic forces on calcitonin gene-related peptide (CGRP) expression in the human periodontal ligament and its relationship with the human dental pulp

2022; Medicina Oral S.L.; Linguagem: Inglês

10.4317/jced.59975

1989-5488

Javier Caviedes‐Bucheli, Jaime Omar Moreno Monsalve, M. Aranguren-Carrero, S. Buitrago-Rojas, R. Lopez-Matheus, G. Martinez-Corredor, Luis E. Díaz, Hernan Dario Muñoz‐Alvear, Jose Francisco Gomez‐Sosa, H. R. Munoz,

Orthodontics and Dentofacial Orthopedics

Background: The purpose of this study was to quantify the effect of moderate and severe orthodontic forces on Calcitonin gene-related peptide (CGRP) expression in the healthy human periodontal ligament (PDL) and its possible relationship with the human dental pulp.Material and Methods: Ninety human periodontal ligament samples were obtained from healthy premolars where extraction was indicated for orthodontic reasons.Prior to extraction, teeth were divided in 3 groups of 30 samples each: I) Untreated teeth control group; II) Moderate force group: A 56 g force was applied to the premolars for 24 hours; and III) Severe force group: A 224 g force was applied to the premolars for 7 days.All periodontal ligament samples were processed and CGRP was measured by radioimmunoassay.