Wnt5A Signaling Regulates Gut Bacterial Survival and T Cell Homeostasis
2022; American Society for Microbiology; Volume: 7; Issue: 6 Linguagem: Inglês
10.1128/msphere.00507-22
ISSN2379-5042
AutoresSoham Sengupta, Suborno Jati, Shreyasi Maity, Malini Sen,
Tópico(s)Pediatric health and respiratory diseases
ResumoGut commensal bacterial diversity and T cell homeostasis are crucial entities of the host innate immune network, yet the molecular details of host-directed signaling pathways that sustain the steady state of gut bacterial colonization and T cell activation remain unclear. Here, we describe the protective role of a Wnt5A-actin axis in the survival of several gut bacterial commensals and its necessity in shaping gut bacterial colonization and the associated T cell repertoire.
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