Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy
2022; American Physical Society; Volume: 324; Issue: 2 Linguagem: Inglês
10.1152/ajprenal.00052.2022
ISSN1931-857X
AutoresMi Ra Noh, Hee‐Seong Jang, Fadi Salem, Fernando Ferrer, Jinu Kim, Babu J. Padanilam,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoEpoxyeicosatrienoic acids (EETs) are cytochrome P-450‐dependent antihypertensive and anti-inflammatory derivatives of arachidonic acid, which are highly abundant in the kidney and considered renoprotective. We found that EET administration and/or soluble epoxide hydrolase inhibition significantly attenuates oxidative stress, renal cell death, inflammation, macrophage differentiation, and fibrogenesis following unilateral ureteral obstruction. Our findings provide a mechanistic understanding of how EETs prevent kidney fibrogenesis during obstructive nephropathy and suggest that EET treatment may be a potential therapeutic strategy to treat fibrotic diseases.
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