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Resveratrol has its antioxidant and anti-inflammatory protective mechanisms decreased in aging

2022; Elsevier BV; Volume: 107; Linguagem: Inglês

10.1016/j.archger.2022.104895

1872-6976

Milena Almeida Santos, Filipe Nogueira Franco, Camila Amaro Caldeira, Glaucy Rodrigues de Araújo, Alessandra Vieira, Mı́riam Martins Chaves,

Antioxidant Activity and Oxidative Stress

In the elderly, there is an increase in oxidative and inflammatory activity. Resveratrol (RSV) is a polyphenol that has several proven biological activities, such as antioxidant and anti-inflammatory. Thus, the aim of our study was to verify the possible antioxidant and anti-inflammatory effects of RSV on human mononuclear cells (PBMCs) from donors aged between 40 and 59 and 60-80 years old. For this, 6-8 patients were selected by age group. Cells were isolated and divided into 4 groups: Control (C), RSV only, H2O2 (to induce an oxidizing environment - C+) and H2O2+RSV. The quantification of reactive nitrogen species (NO and ONOO-), as well as pro and anti-inflammatory cytokines (TNFα, IL-6 and IL-10) was performed. Pearson's correlation and comparison between groups were performed (p<0.05). Our results showed a greater role of RSV in the middle-aged compared to the elderly group, in relation to the balance of NO/ONOO- and the levels of cytokines IL-6 and TNFα. It was also possible to observe an improvement in the anti-inflammatory profile in both age groups, but more effective in the cells in the middle-aged group. Thus, we could observe that RSV has better activity in the reduction of important biomarkers of oxidation and inflammation.