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BIBTEX RIS

Resistance Training Improves Sleep and Anti-Inflammatory Parameters in Sarcopenic Older Adults: A Randomized Controlled Trial

2022; Multidisciplinary Digital Publishing Institute; Volume: 19; Issue: 23 Linguagem: Inglês

10.3390/ijerph192316322

ISSN

1661-7827

Autores

Helton de Sá Souza, Camila Maria de Melo, Ronaldo D. Piovezan, Rafael Eduardo Eustórgio Pinheiro Chagas Miranda, Miguel Araújo Carneiro‐Júnior, Bruno M. Silva, Ronaldo Vagner Thomatieli dos Santos, Sérgio Tufik, Dalva Poyares, Vânia D’Almeida,

Tópico(s)

Exercise and Physiological Responses

Resumo

Sleep and exercise have an important role in the development of several inflammation-related diseases, including sarcopenia. Objective: To investigate the effects of 12 weeks of resistance exercise training on sleep and inflammatory status in sarcopenic patients. Methods: A randomized controlled trial comparing resistance exercise training (RET) with a control (CTL) was conducted. Outcomes were obtained by physical tests, polysomnography, questionnaires, isokinetic/isometric dynamometry tests, and biochemical analysis. Results: Time to sleep onset (sleep latency) was reduced in the RET group compared to the CTL group (16.09 ± 15.21 vs. 29.98 ± 16.09 min; p = 0.04) after the intervention. The percentage of slow-wave sleep (N3 sleep) was increased in the RET group (0.70%, CI: 7.27–16.16 vs. −4.90%, CI: 7.06–16.70; p = 0.04) in an intention to treat analysis. Apnea/hour was reduced in the RET group (16.82 ± 14.11 vs. 7.37 ± 7.55; p = 0.001) and subjective sleep quality was improved compared to the CTL (−1.50; CI: 2.76–6.14 vs. 0.00; CI: 1.67–3.84 p = 0.02) in an intention-to-treat analysis. Levels of interleukin-10 (IL-10) (2.13 ± 0.80 vs. 2.51 ± 0.99; p < 0.03) and interleukin-1 receptor antagonist (IL-1ra) (0.99 ± 0.10 vs. 0.99 ± 0.10 ng/mL; p < 0.04; delta variation) were increased in the RET group. Conclusions: RET improves sleep parameters linked to muscle performance, possibly due to an increase in anti-inflammatory markers in older sarcopenic patients.

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