Produção Nacional
Revisado por pares
Antioxidant and anti-inflammatory activity of curcumin transdermal gel in an IL-10 knockout mouse model of inflammatory bowel disease
2022; Brazilian Academy of Sciences; Volume: 94; Issue: 4 Linguagem: Inglês
10.1590/0001-3765202220201378
ISSN1678-2690
AutoresFernanda Ferreira de Araújo, Matheus Brum Felício, Cássio Furtado Lima, Mayra Soares Píccolo, Virgínia Ramos Pizziolo, Gaspar Diaz‐Muñoz, Daniel Silva Sena Bastos, Leandro Licursi de Oliveira, Maria do Carmo Gouveia Pelúzio, Marisa Alves Nogueira Diaz,
Tópico(s)Pharmacological Effects of Natural Compounds
ResumoInflammatory bowel diseases are a group of inflammatory disorders of the gastrointestinal tract. Their prevalence is still low in Brazil, but the incidence is increasing annually. A variety of compounds present in Curcuma longa L., particularly curcumin, have been shown to reduce oxidative stress and aid in the prevention of associated diseases. This study aimed to assess the effect of curcumin transdermal gel on oxidative stress and intestinal inflammation in IL-10 knockout mice. Female mice were divided into four groups: a control group (C0) treated with vehicle and three experimental groups treated with transdermal gel containing 50 (C50), 75 (C75), and 100 (C100) mg curcumin kg−1 body weight. Colon malondialdehyde concentrations were lower in C50 and C75 groups. C100 treatment led to reduced catalase activity in the small intestine, whereas C50, C75, and C100 treatments resulted in decreased catalase activity in the colon. In contrast, superoxide dismutase activity increased in the small intestine of C50 and C75 mice and decreased in the colon of C50, C75, and C100 mice. Glutathione S-transferase activity increased in the small intestine and decreased in the colon of C75 animals. These findings suggest that curcumin transdermal gel exerts a protective effect against oxidative stress.
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