Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab ( B‐PAD study)
2022; Wiley; Volume: 53; Issue: 2 Linguagem: Inglês
10.1111/cea.14267
ISSN1365-2222
AutoresTakeshi Nakahara, Kenji Izuhara, Daisuke Onozuka, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Michihiro Hide, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido‐Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa‐Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda‐Hirose, Yutaka Hatano, Hiroshi Kawasaki, Keiji Tanese, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue,
Tópico(s)Allergic Rhinitis and Sensitization
ResumoClinical & Experimental AllergyVolume 53, Issue 2 p. 233-238 RESEARCH LETTER Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study) Takeshi Nakahara, Corresponding Author Takeshi Nakahara [email protected] Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Correspondence Takeshi Nakahara, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Email: [email protected]Search for more papers by this authorKenji Izuhara, Kenji Izuhara orcid.org/0000-0002-6983-907X Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, JapanSearch for more papers by this authorDaisuke Onozuka, Daisuke Onozuka orcid.org/0000-0001-9596-9188 Department of Oral Microbe Control, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorHidehisa Saeki, Hidehisa Saeki Department of Dermatology, Nippon Medical School, Tokyo, JapanSearch for more papers by this authorSatoshi Nunomura, Satoshi Nunomura orcid.org/0000-0002-9315-4185 Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, JapanSearch for more papers by this authorMotoi Takenaka, Motoi Takenaka Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanSearch for more papers by this authorMai Matsumoto, Mai Matsumoto Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanSearch for more papers by this authorYoko Kataoka, Yoko Kataoka Department of Dermatology, Osaka Habikino Medical Center, Osaka, JapanSearch for more papers by this authorRai Fujimoto, Rai Fujimoto Department of Dermatology, Osaka Habikino Medical Center, Osaka, JapanSearch for more papers by this authorSakae Kaneko, Sakae Kaneko Department of Dermatology, Shimane University Faculty of Medicine, Shimane, JapanSearch for more papers by this authorEishin Morita, Eishin Morita orcid.org/0000-0002-5427-8468 Department of Dermatology, Shimane University Faculty of Medicine, Shimane, JapanSearch for more papers by this authorAkio Tanaka, Akio Tanaka Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanSearch for more papers by this authorMichihiro Hide, Michihiro Hide Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanSearch for more papers by this authorTatsuro Okano, Tatsuro Okano Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, JapanSearch for more papers by this authorTomomitsu Miyagaki, Tomomitsu Miyagaki Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, JapanSearch for more papers by this authorNatsuko Aoki, Natsuko Aoki Department of Dermatology, Kochi Medical School, Kochi, JapanSearch for more papers by this authorKimiko Nakajima, Kimiko Nakajima Department of Dermatology, Kochi Medical School, Kochi, JapanSearch for more papers by this authorSusumu Ichiyama, Susumu Ichiyama Department of Dermatology, Nippon Medical School, Tokyo, JapanSearch for more papers by this authorMakiko Kido-Nakahara, Makiko Kido-Nakahara Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this authorKyoko Tonomura, Kyoko Tonomura Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorYukinobu Nakagawa, Yukinobu Nakagawa Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorRisa Tamagawa-Mineoka, Risa Tamagawa-Mineoka orcid.org/0000-0001-9379-9584 Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorKoji Masuda, Koji Masuda Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorTakuya Takeichi, Takuya Takeichi Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, JapanSearch for more papers by this authorMasashi Akiyama, Masashi Akiyama Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, JapanSearch for more papers by this authorYozo Ishiuji, Yozo Ishiuji Department of Dermatology, The Jikei University School of Medicine, Tokyo, JapanSearch for more papers by this authorMichie Katsuta, Michie Katsuta Department of Dermatology, The Jikei University School of Medicine, Tokyo, JapanSearch for more papers by this authorYuki Kinoshita, Yuki Kinoshita Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanSearch for more papers by this authorChiharu Tateishi, Chiharu Tateishi Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanSearch for more papers by this authorAya Yamamoto, Aya Yamamoto Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, JapanSearch for more papers by this authorAkimichi Morita, Akimichi Morita Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, JapanSearch for more papers by this authorHaruna Matsuda-Hirose, Haruna Matsuda-Hirose Department of Dermatology, Faculty of Medicine, Oita University, Oita, JapanSearch for more papers by this authorYutaka Hatano, Yutaka Hatano Department of Dermatology, Faculty of Medicine, Oita University, Oita, JapanSearch for more papers by this authorHiroshi Kawasaki, Hiroshi Kawasaki Department of Dermatology, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this authorKeiji Tanese, Keiji Tanese Department of Dermatology, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this authorMamitaro Ohtsuki, Mamitaro Ohtsuki Department of Dermatology, Jichi Medical University, Tochigi, JapanSearch for more papers by this authorKoji Kamiya, Koji Kamiya Department of Dermatology, Jichi Medical University, Tochigi, JapanSearch for more papers by this authorYudai Kabata, Yudai Kabata Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanSearch for more papers by this authorRiichiro Abe, Riichiro Abe Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanSearch for more papers by this authorHiroshi Mitsui, Hiroshi Mitsui Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, JapanSearch for more papers by this authorTatsuyoshi Kawamura, Tatsuyoshi Kawamura Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, JapanSearch for more papers by this authorGaku Tsuji, Gaku Tsuji Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this authorNorito Katoh, Norito Katoh Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorMasutaka Furue, Masutaka Furue Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this author Takeshi Nakahara, Corresponding Author Takeshi Nakahara [email protected] Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan Correspondence Takeshi Nakahara, Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Email: [email protected]Search for more papers by this authorKenji Izuhara, Kenji Izuhara orcid.org/0000-0002-6983-907X Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, JapanSearch for more papers by this authorDaisuke Onozuka, Daisuke Onozuka orcid.org/0000-0001-9596-9188 Department of Oral Microbe Control, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorHidehisa Saeki, Hidehisa Saeki Department of Dermatology, Nippon Medical School, Tokyo, JapanSearch for more papers by this authorSatoshi Nunomura, Satoshi Nunomura orcid.org/0000-0002-9315-4185 Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, JapanSearch for more papers by this authorMotoi Takenaka, Motoi Takenaka Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanSearch for more papers by this authorMai Matsumoto, Mai Matsumoto Department of Dermatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, JapanSearch for more papers by this authorYoko Kataoka, Yoko Kataoka Department of Dermatology, Osaka Habikino Medical Center, Osaka, JapanSearch for more papers by this authorRai Fujimoto, Rai Fujimoto Department of Dermatology, Osaka Habikino Medical Center, Osaka, JapanSearch for more papers by this authorSakae Kaneko, Sakae Kaneko Department of Dermatology, Shimane University Faculty of Medicine, Shimane, JapanSearch for more papers by this authorEishin Morita, Eishin Morita orcid.org/0000-0002-5427-8468 Department of Dermatology, Shimane University Faculty of Medicine, Shimane, JapanSearch for more papers by this authorAkio Tanaka, Akio Tanaka Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanSearch for more papers by this authorMichihiro Hide, Michihiro Hide Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, JapanSearch for more papers by this authorTatsuro Okano, Tatsuro Okano Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, JapanSearch for more papers by this authorTomomitsu Miyagaki, Tomomitsu Miyagaki Department of Dermatology, St. Marianna University School of Medicine, Kanagawa, JapanSearch for more papers by this authorNatsuko Aoki, Natsuko Aoki Department of Dermatology, Kochi Medical School, Kochi, JapanSearch for more papers by this authorKimiko Nakajima, Kimiko Nakajima Department of Dermatology, Kochi Medical School, Kochi, JapanSearch for more papers by this authorSusumu Ichiyama, Susumu Ichiyama Department of Dermatology, Nippon Medical School, Tokyo, JapanSearch for more papers by this authorMakiko Kido-Nakahara, Makiko Kido-Nakahara Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this authorKyoko Tonomura, Kyoko Tonomura Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorYukinobu Nakagawa, Yukinobu Nakagawa Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, JapanSearch for more papers by this authorRisa Tamagawa-Mineoka, Risa Tamagawa-Mineoka orcid.org/0000-0001-9379-9584 Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorKoji Masuda, Koji Masuda Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorTakuya Takeichi, Takuya Takeichi Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, JapanSearch for more papers by this authorMasashi Akiyama, Masashi Akiyama Department of Dermatology, Nagoya University Graduate School of Medicine, Aichi, JapanSearch for more papers by this authorYozo Ishiuji, Yozo Ishiuji Department of Dermatology, The Jikei University School of Medicine, Tokyo, JapanSearch for more papers by this authorMichie Katsuta, Michie Katsuta Department of Dermatology, The Jikei University School of Medicine, Tokyo, JapanSearch for more papers by this authorYuki Kinoshita, Yuki Kinoshita Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanSearch for more papers by this authorChiharu Tateishi, Chiharu Tateishi Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, JapanSearch for more papers by this authorAya Yamamoto, Aya Yamamoto Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, JapanSearch for more papers by this authorAkimichi Morita, Akimichi Morita Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Aichi, JapanSearch for more papers by this authorHaruna Matsuda-Hirose, Haruna Matsuda-Hirose Department of Dermatology, Faculty of Medicine, Oita University, Oita, JapanSearch for more papers by this authorYutaka Hatano, Yutaka Hatano Department of Dermatology, Faculty of Medicine, Oita University, Oita, JapanSearch for more papers by this authorHiroshi Kawasaki, Hiroshi Kawasaki Department of Dermatology, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this authorKeiji Tanese, Keiji Tanese Department of Dermatology, School of Medicine, Keio University, Tokyo, JapanSearch for more papers by this authorMamitaro Ohtsuki, Mamitaro Ohtsuki Department of Dermatology, Jichi Medical University, Tochigi, JapanSearch for more papers by this authorKoji Kamiya, Koji Kamiya Department of Dermatology, Jichi Medical University, Tochigi, JapanSearch for more papers by this authorYudai Kabata, Yudai Kabata Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanSearch for more papers by this authorRiichiro Abe, Riichiro Abe Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, JapanSearch for more papers by this authorHiroshi Mitsui, Hiroshi Mitsui Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, JapanSearch for more papers by this authorTatsuyoshi Kawamura, Tatsuyoshi Kawamura Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, JapanSearch for more papers by this authorGaku Tsuji, Gaku Tsuji Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this authorNorito Katoh, Norito Katoh Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, JapanSearch for more papers by this authorMasutaka Furue, Masutaka Furue Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanSearch for more papers by this author First published: 16 December 2022 https://doi.org/10.1111/cea.14267Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1Simpson EL, Bieber T, Guttman-Yassky E, et al. SOLO 1 and SOLO 2 investigators. Two phase 3 trials of dupilumab versus placebo in atopic dermatitis. N Engl J Med. 2016; 375(24): 2335-2348. 10.1056/NEJMoa1610020 CASPubMedWeb of Science®Google Scholar 2Simpson EL, Paller AS, Siegfried EC, et al. Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 randomized clinical trial. JAMA Dermatol. 2020; 156(1): 44-56. 10.1001/jamadermatol.2019.3336 PubMedWeb of Science®Google Scholar 3Nakahara T, Kido-Nakahara M, Onozuka D, et al. Efficacy of dupilumab for atopic dermatitis according to clinical course and clinical findings: a multicentre retrospective study. Acta Derm Venereol. 2021; 101(11):adv00586. 10.2340/actadv.v101.369 PubMedWeb of Science®Google Scholar 4Kamata M, Tada Y. A literature review of real-world effectiveness and safety of dupilumab for atopic dermatitis. JID Innov. 2021; 1(3):100042. 10.1016/j.xjidi.2021.100042 PubMedGoogle Scholar 5Bieber T. Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy. 2012; 67(12): 1475-1482. 10.1111/all.12049 CASPubMedWeb of Science®Google Scholar 6Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, et al. Moving toward endotypes in atopic dermatitis: identification of patient clusters based on serum biomarker analysis. J Allergy Clin Immunol. 2017; 140(3): 730-737. 10.1016/j.jaci.2017.03.023 CASPubMedWeb of Science®Google Scholar 7Schmitt J, Spuls PI, Thomas KS, et al. HOME initiative collaborators. The Harmonising outcome measures for eczema (HOME) statement to assess clinical signs of atopic eczema in trials. J Allergy Clin Immunol. 2014; 134(4): 800-807. 10.1016/j.jaci.2014.07.043 PubMedWeb of Science®Google Scholar 8Egeberg A, Anderson P, Piercy J, et al. Symptom burden of patients with moderate-to-severe atopic dermatitis. Eur J Dermatol. 2021; 31(6): 752-758. 10.1684/ejd.2021.4166 PubMedWeb of Science®Google Scholar 9Nakahara T, Fujita H, Arima K, Taguchi Y, Motoyama S, Furue M. Treatment satisfaction in atopic dermatitis relates to patient-reported severity: a cross-sectional study. Allergy. 2019; 74(6): 1179-1181. 10.1111/all.13712 CASPubMedWeb of Science®Google Scholar Volume53, Issue2February 2023Pages 233-238 ReferencesRelatedInformation
Referência(s)