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Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTRs: results from two prospective cohort studies

2022; Oxford University Press; Volume: 38; Issue: 4 Linguagem: Inglês

10.1093/ndt/gfac332

1460-2385

Daan Kremer, Firas Farisi Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, M.A. Karsdal, Daniel Guldager Kring Rasmussen, Stephan J. L. Bakker,

Systemic Sclerosis and Related Diseases

Fibrosis is a suggested cause of graft failure and mortality among kidney transplant recipients (KTRs). Accumulating evidence suggests that collagen type VI is tightly linked to fibrosis and may be a marker of systemic fibrosis and ageing. We studied whether plasma endotrophin, a pro-collagen type VI fragment, is associated with graft failure and mortality among KTRs.