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Circulating adipose tissue proteins involved in atrial fibrillation: An explorative scoping review

2022; Elsevier BV; Volume: 34; Issue: 3 Linguagem: Inglês

10.1016/j.tcm.2022.12.004

1873-2615

Eva R. Meulendijks, Sébastien P.J. Krul, Sarah W.E. Baalman, Tim A.C. de Vries, Robin Wesselink, Auriane C. Ernault, Makiri Kawasaki, Rushd Al‐Shama, Jolien Neefs, Jacqueline Limpens, Joris R. de Groot,

Adipose Tissue and Metabolism

Obesity increases the risk of atrial fibrillation (AF), potentially through proteins secreted by adipose tissue (AT) that affect atrial electrical and structural remodeling. We aim to give a comprehensive overview of circulating AT proteins that are associated with prevalent (paroxysmal or persistent AF) and the risk on developing new-onset AF that are involved in inflammation and fibrosis. These include adipokines, defined as proteins enriched in AT as adiponectin, but also proteins less specific to AT. We systematically performed an explorative search for studies reporting associations between proteins secreted from cells residing in the AT and AF, and additionally assessed the effect of obesity on all proteins by a secondary search. The AT proteins involved in inflammation were mostly increased in prevalent and new-onset AF patients and obesity, while the AT enriched adipokines were mostly not associated with AF. This review provides insight into circulating adipose tissue proteins involved in AF substrate formation.