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Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration

2022; Elsevier BV; Volume: 7; Issue: 5 Linguagem: Inglês

10.1016/j.oret.2022.12.007

2468-7219

Marlene Saßmannshausen, Charlotte Behning, Jonas Weinz, Lukas Goerdt, Jan Henrik Terheyden, Petrus Chang, Matthias Schmid, Stephen Poor, Nadia Zakaria, Robert P. Finger, Frank G. Holz, Maximilian Pfau, Steffen Schmitz-Valckenberg, Sarah Thiele, Hansjürgen Agostini, Lebriz Altay, R. Atia, Francesco Bandello, P. G. Basile, Charlotte Behning, M. Belmouhand, Moritz Berger, Alison M. Binns, Camiel J.F. Boon, M. Böttger, Christine Bouchet, John Brazier, Thomas Butt, C. Carapezzi, Jill Carlton, Ângela Carneiro, A. Charil, Raúl Coimbra, M. Cozzi, David P. Crabb, José Cunha‐Vaz, Claudia Dahlke, Luís de Sisternes, Hannah Dunbar, Robert P. Finger, Emily Fletcher, H. Floyd, C. Francisco, M. Gutfleisch, Ruth Hogg, Frank G. Holz, Carel B. Hoyng, A. Kilani, J. Krätzschmar, L. Kühlewein, Michael Larsen, Sérgio Leal, Yara T. E. Lechanteur, Ulrich F. O. Luhmann, A. Lüning, I. Marques, Cecília Martinho, Giovanni Montesano, Z. Mulyukov, Michel Pâques, Maurízio Battaglia Parodi, M. Parravano, S. Penas, Terry M. Peters, Tünde Pető, Maximilian Pfau, Stephen Poor, Siegfried Priglinger, Donna Rowen, Gary S. Rubin, J. Sahel, Clarisa Sánchez, O. Sander, Marlene Saßmannshausen, Matthias Schmid, Steffen Schmitz-Valckenberg, H. Schrinner-Fenske, J. Siedlecki, Rufino Silva, A. Skelly, E. Souied, Giovanni Staurenghi, L. Stöhr, David J. Taylor, Jan Henrik Terheyden, Sarah Thiele, Adnan Tufail, M. Varano, L. Vieweg, Ludmila Wintergerst, Armin Wolf, Nadia Zakaria,

Glaucoma and retinal disorders

To report the prevalence and topographic distribution of structural characteristics in study participants with age-related macular degeneration (AMD) and controls in the cross-sectional study part of the MACUSTAR study (ClinicalTrials.gov Identifier: NCT03349801).European, multicenter cohort study.Overall, 301 eyes of 301 subjects with early (n = 34), intermediate (n = 168), and late AMD (n = 43), as well as eyes without any AMD features (n = 56).In study eyes with intermediate AMD (iAMD), the presence of structural AMD biomarkers, including pigmentary abnormalities (PAs), pigment epithelium detachment (PED), refractile deposits, reticular pseudodrusen (RPD), hyperreflective foci (HRF), incomplete/complete retinal pigment epithelium (RPE), and outer retinal atrophy (i/cRORA), and quiescent choroidal neovascularization (qCNV) was systematically determined in the prospectively acquired multimodal retinal imaging cross-sectional data set of MACUSTAR. Retinal layer thicknesses and the RPE drusen complex (RPEDC) volume were determined for the total study cohort in spectral-domain (SD) OCT imaging using a deep-learning-based algorithm.Prevalence and topographic distribution of structural iAMD features.A total of 301 study eyes of 301 subjects with a mean (± standard deviation) age of 71.2 ± 7.20 years (63.1% women) were included. Besides large drusen, the most prevalent structural feature in iAMD study eyes were PA (57.1%), followed by HRF (51.8%) and RPD (22.0%). Pigment epithelium detachment lesions were observed in 4.8%, vitelliform lesions in 4.2%, refractile deposits in 3.0%, and qCNV in 2.4%. Direct precursor lesions for manifest retinal atrophy were detected in 10.7% (iRORA) and 4.2% (cRORA) in iAMD eyes. Overall, the highest RPEDC volume with a median of 98.92 × 10-4 mm³ was found in iAMD study eyes. Spatial analysis demonstrated a predominant distribution of RPD in the superior and temporal subfields at a foveal eccentricity of 1.5 to 2 mm, whereas HRF and large drusen had a distinct topographic distribution involving the foveal center.Detailed knowledge of the prevalence and distribution of structural iAMD biomarkers is vital to identify reliable outcome measure for disease progression. Longitudinal analyses are needed to evaluate their prognostic value for conversion to advanced disease stages.Proprietary or commercial disclosure may be found after the references.