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BIBTEX RIS

Pluronic® triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview

2022; Elsevier BV; Volume: 353; Linguagem: Inglês

10.1016/j.jconrel.2022.12.017

1873-4995

Karine Cappuccio de Castro, Julia Cedran Coco, Érica Mendes dos Santos, Janaína Artem Ataide, Renata Miliani Martinez, Mônica H. M. Nascimento, João Prata, Pedro Fonte, Patrícia Severino, Priscila Gava Mazzola, André Rolim Baby, Eliana B. Souto, Daniele Ribeiro de Araújo, André Moreni Lopes,

Advanced Drug Delivery Systems

This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to innovative examples for improving tumor cytotoxicity while reducing side effects.