Portal de Periódicos da CAPES

Biocompatibility Analysis of GelMa Hydrogel and Silastic RTV 9161 Elastomer for Encapsulation of Electronic Devices for Subdermal Implantable Devices

2022; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 1 Linguagem: Inglês

10.3390/coatings13010019

2079-6412

David Dragomir, Vlad Carbunaru, Carmen Moldovan, Ioan Lascăr, Octavian Donţu, Violeta Ristoiu, Roxana Gheorghe, A Oproiu, Bogdan Firtat, Eduard Franți, Monica Dascălu, Tiberiu Paul Neagu, Dan Mircea Enescu, Octavian Ionescu, Marian Ion, Carmen-Marinela Mihăilescu, Ruxandra Costea, Magda Gonciarov, G Ionescu, Adrian Dumitru, Anca Minca, Catalin Niculae, Ştefania Raită, Ioana Roşca, Sorin Lăzărescu, Cristian Ioan Stoica, Raluca Ioana Teleanu, Daniel Mihai Teleanu,

Advanced Sensor and Energy Harvesting Materials

The natural differences between human-made electronics and biological tissues constitute a huge challenge in materials and the manufacturing of next-generation bioelectronics. As such, we performed a series of consecutive experiments for testing the biofunctionality and biocompatibility for device implantation, by changing the exterior chemical and physical properties of electronics coating it with silicone or hydrogels. In this article, we present a comparison of the main characteristics of an electronic device coated with either silicone or hydrogel (GelMa). The coating was performed with a bioprinter for accurate silicone and hydrogel deposition around different electronic chips (Step-Down Voltage Regulator U3V15F5 from Pololu Corporation). The results demonstrate that the hydrogel coating presents an augmented biomechanical and biochemical interface and superior biocompatibility, lowers foreign body response, and considerably extends the capabilities for bioelectronic applications.