Portal de Periódicos da CAPES

Revisão Produção Nacional Revisado por pares

BIBTEX RIS

Premotor, nonmotor and motor symptoms of Parkinson's Disease: A new clinical state of the art

2022; Elsevier BV; Volume: 84; Linguagem: Inglês

10.1016/j.arr.2022.101834

1872-9649

Ana Beatriz Ramalho Leite Silva, Roger Wilson Gonçalves de Oliveira, Guilherme Pinheiro Diógenes, Marina Feitosa de Castro Aguiar, Camilla Costa Sallem, Micael Porto Portela Lima, Luciano Barroso de Albuquerque Filho, Sara Diógenes Peixoto de Medeiros, Lucas Lopes Penido de Mendonça, Paulo Cesar de Santiago Filho, Diogo Pasquali Nones, Pamella Mendes Martiniano da Silva Cardoso, Michelle Zonkowski Ribas, Stéfani Lara Galvão, Gabriel Felipe Gomes, Amanda Rebouças Bezerra de Menezes, Nayla Lima dos Santos, Victor Monteiro Mororó, Fairane Sousa Duarte, Júlio César Claudino dos Santos,

Restless Legs Syndrome Research

Parkinson's Disease (PD) is a neurodegenerative disorder that affects dopaminergic neurons in the mesencephalic substantia nigra, causing a progressive clinical course characterized by pre-motor, non-motor and motor symptoms, which negatively impact the quality of life of patients and cause high health care costs. Therefore, the present study aims to discuss the clinical manifestations of PD and to make a correlation with the gut-brain (GB) axis, approaching epidemiology and therapeutic perspectives, to better understand its clinical progression and identify symptoms early. A literature review was performed regarding the association between clinical progression, the gut-brain axis, epidemiology, and therapeutic perspectives, in addition to detailing pre-motor, non-motor symptoms (neuropsychiatric, cognitive, autonomic, sleep disorders, sensory abnormalities) and cardinal motor symptoms. Therefore, this article addresses a topic of extreme relevance, since the previously mentioned clinical manifestations (pre-motor and non-motor) can often act as prodromal markers for the early diagnosis of PD and may precede it by up to 20 years.