Anti-Tumor Immunity in B Lymphocyte-Deprived Mice
1978; American Association of Immunologists; Volume: 121; Issue: 1 Linguagem: Inglês
10.4049/jimmunol.121.1.359
ISSN1550-6606
Autores Tópico(s)RNA Interference and Gene Delivery
ResumoAbstract Immunity to a syngeneic methylcholanthrene-induced tumor was studied in (C57BL/6 × C3H)F1 males, treated continuously from birth with a rabbit anti-mouse IgM serum. Such mice have been shown to be selectively depleted of Ig-bearing lymphocytes and incapable of synthesizing antibodies. In the experiments reported, a heightened resistance of these mice to the syngeneic fibrosarcoma was demonstrated. This resistance was manifest in significantly slower tumor growth at the site of injection, as well as a lower incidence of spontaneous pulmonary metastasis.
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