The Immunological Specificity of Sulfonamide Protein Conjugates As Demonstrated by Anaphylaxis in Guinea-Pigs and the Shwartzman Phenomenon in Rabbits
1944; American Association of Immunologists; Volume: 48; Issue: 2 Linguagem: Inglês
10.4049/jimmunol.48.2.103
ISSN1550-6606
AutoresIsadore E. Gerber, Milton D. Gross,
Tópico(s)Protein purification and stability
ResumoSummary Anaphylactic shock is readily elicited in guinea-pigs sensitized to sulfona-mide azo proteins, following the intravenous introduction of the homologous sulfonamide-conjugate, the homologous native protein, or a related sulfonamide-hapten conjugated with a heterologous protein. More precise demonstration of the interaction of various sulfonamide azo proteins was obtained by a simplified technic of intravenous injection in guineapigs. Similar experiences were obtained in rabbits utilizing the Shwartzman phenomenon as an index of antigen-antibody reaction. The experimental evidence confirms the clinical experience of the specificity of human hypersensitivity to various sulfonamides.
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