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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

2022; Nature Portfolio; Volume: 2; Issue: 12 Linguagem: Inglês

10.1038/s43587-022-00326-5

2662-8465

Patty J. Lee, Christopher C. Benz, Philip D. Blood, Katy Börner, Judith Campisi, Feng Chen, Heike E. Daldrup‐Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, David Furman, Vesna D. Garovic, Nils Gehlenborg, Carolyn Glass, Indra Heckenbach, Ziv-Bar Joseph, Pragati Katiyar, Sojin Kim, Mélanie Königshoff, George A. Kuchel, Haesung Lee, Jun Hee Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera‐Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Morten Scheibye‐Knudsen, Birgit Schilling, Pixu Shi, Jonathan C. Silverstein, Vidyani Suryadevara, Jichun Xie, Jinhua Wang, A. Ian Wong, Laura J. Niedernhofer, Siyuan Wang, Hannah Anvari, Julia L. Balough, Christopher C. Benz, Joanna Bons, Boris Brenerman, William J. Evans, Akos A. Gerencser, Heather Gregory, Malene Hansen, Jamie N. Justice, Pankaj Kapahi, Natália Faraj Murad, Amy O’Broin, Mary Ellen Pavone, Mark Powell, Gary K. Scott, Elisheva D. Shanes, Mahalakshmi Shankaran, Eric Verdin, Daniel A. Winer, Fei Wu, Andrew I. Adams, Philip D. Blood, Andreas Bueckle, Ivan Cao-Berg, Hao Chen, Michael J. Davis, Shane Filus, Yuhan Hao, Austin Hartman, Euxhen Hasanaj, Jesse Helfer, Bruce Herr, Ziv Bar‐Joseph, Gesmira Molla, Gloria Mou, Juan Puerto, Ellen M. Quardokus, Alexander J. Ropelewski, Matt Ruffalo, Rahul Satija, Melissa Schwenk, Robin Scibek, William Shirey, Max Sibilla, Joel Welling, Yuan Zhou, Richard Bonneau, Angela M. Christiano, Benjamin Izar, Vilas Menon, David M. Owens, Hemali Phatnani, Colin Smith, Yousin Suh, Andrew F. Teich, Valerie Bekker, Cliburn Chan, Elias Coutavas, Matthew G. Hartwig, Zhicheng Ji, Andrew B. Nixon, Zhixun Dou, Jayaraj Rajagopal, Nikolai Slavov, David R. Holmes, Diana Jurk, James L. Kirkland, Anthony B. Lagnado, Tamar Tchkonia, Kristin Abraham, Amanda M. DiBattista, Yih-Woei C. Fridell, T. Kevin Howcroft, Chamelli Jhappan, Viviana Perez Montes, Mercy PrabhuDas, Haluk Resat, Veronica Taylor, Manoj Kumar, Vidyani Suryadevara, Francisco Cigarroa, Rachel Cohn, Tiffany Cortes, Elise T. Courtois, Jeffrey H. Chuang, Monica Davé, Sergii Domanskyi, Elizabeth Ann L. Enninga, Giray Naim Eryilmaz, Sara Espinoza, Jon Gelfond, James L. Kirkland, George A. Kuchel, Chia‐Ling Kuo, Julia S. Lehman, Cristina Aguayo‐Mazzucato, Alexander Meves, Meenakshi Rani, William S. Sanders, Asa Thibodeau, Stefan G. Tullius, Duygu Ucar, Brian S. White, Qian Wu, Ming Xu, Seiji Yamaguchi, Naziheh Assarzadegan, Chun‐Seok Cho, Irene Hwang, Yongha Hwang, Jingyue Xi, Oyedele Adeyi, Constantin Aliferis, Alessandro Bartolomucci, Xiao Dong, Mickayla J. DuFresne-To, Sayeed Ikramuddin, Steve Johnson, Andrew C. Nelson, Laura J. Niedernhofer, Xavier S. Revelo, Claudia Trevilla‐García, John M. Sedivy, Elizabeth L. Thompson, Paul D. Robbins, Jinhua Wang, Katherine M. Aird, Jonathan K. Alder, Delphine Beaulieu, Marta Bueno, Jazmín Calyeca, Julián A. Chamucero-Millaris, Stephen Y. Chan, Dongjun Chung, Anthony Corbett, Vera Gorbunova, Kymberly M. Gowdy, Aditi U. Gurkar, Jeffrey C. Horowitz, Qianjiang Hu, Gagandeep Kaur, Timur O. Khaliullin, Robert Lafyatis, Serafina Lanna, Dongmei Li, Anjun Ma, Alison Morris, Thivanka Muthumalage, Victor Peters, Gloria Pryhuber, Brenda F. Reader, Lorena Rosas, John Sembrat, Sadiya Bi Shaikh, Hangchuan Shi, Sean D. Stacey, Claudette M. St. Croix, Cankun Wang, Qixin Wang, Andrew Watts, Liangcai Gu, Yiing Lin, Peter S. Rabinovitch, Mariya T. Sweetwyne, Maxim N. Artyomov, Samuel Ballentine, Milan G. Chheda, Sherri R. Davies, John F. DiPersio, Ryan C. Fields, James A. J. Fitzpatrick, Robert S. Fulton, Shin‐ichiro Imai, Sanjay Jain, Tao Ju, Vladimir Kushnir, Daniel C. Link, Michael Ben Major, Stephen T. Oh, Daniel Rapp, Michael P. Rettig, Shelia Stewart, Deborah J. Veis, Kiran Vij, Michael C. Wendl, Matthew A. Wyczalkowski, Joseph Craft, Archibald Enninful, Negin Farzad, Peter Gershkovich, Stephanie Halene, Yuval Kluger, Jennifer VanOudenhove, Mina L. Xu, Junchen Yang, Ming‐Yu Yang,

Genetics, Aging, and Longevity in Model Organisms

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a proinflammatory senescence-associated secretory phenotype. The heterogeneity of senescent cells (SnCs) and senescence-associated secretory phenotype are vast, yet ill characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and their detection a priority. The Cellular Senescence Network (SenNet), a National Institutes of Health Common Fund initiative, was established to address this need. The goal of SenNet is to map SnCs across the human lifespan to advance diagnostic and therapeutic approaches to improve human health. State-of-the-art methods will be applied to identify, define and map SnCs in 18 human tissues. A common coordinate framework will integrate data to create four-dimensional SnC atlases. Other key SenNet deliverables include innovative tools and technologies to detect SnCs, new SnC biomarkers and extensive public multi-omics datasets. This Perspective lays out the impetus, goals, approaches and products of SenNet. This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.