Produção Nacional
Revisado por pares
Post-acute sequelae of SARS-CoV-2 associates with physical inactivity in a cohort of COVID-19 survivors
2023; Nature Portfolio; Volume: 13; Issue: 1 Linguagem: Inglês
10.1038/s41598-022-26888-3
ISSN2045-2322
AutoresSaulo Gil, Bruno Gualano, Adriana Ladeira de Araújo, Gersiel Nascimento de Oliveira Júnior, Rodolfo Furlan Damiano, Fábio Pinna, Marta Imamura, Vanderson Rocha, Esper G. Kallás, Linamara Rizzo Battistella, Orestes Vicente Forlenza, Carlos Roberto Ribeiro de Carvalho, Geraldo F. Busatto, Hamilton Roschel, Edivaldo Utiyama, Aluísio Augusto Cotrim Segurado, Beatriz Perondi, Anna Miethke-Morais, Amanda C. Montal, Leila Suemi Harima Letaif, Solange Fusco, Marjorie Fregonesi Rodrigues da Silva, Marcelo Salles Rocha, Izabel Marcílio, Izabel Cristina Rios, Fabiane Yumi Ogihara Kawano, Maria Amélia de Jesus, Esper G. Kallás, Carolina Carmo, Clarice Tanaka, Heraldo Possolo de Souza, Júlio Flávio Meirelles Marchini, Carlos Roberto Ribeiro de Carvalho, Juliana Carvalho Ferreira, Maura Salaroli de Oliveira, Thaís Guimarães, Carolina dos Santos Lázari, Alberto José da Silva Duarte, Ester Sabino, Marcello Mihailenko Chaves Magri, Tarcisio E. P. Barros-Filho, Maria Cristina Peres Braido Francisco,
Tópico(s)Fibromyalgia and Chronic Fatigue Syndrome Research
ResumoThe aim of this study was to determine whether Post-acute Sequelae of SARS-CoV-2 Infection (PASC) are associated with physical inactivity in COVID-19 survivors. This is a cohort study of COVID-19 survivors discharged from a tertiary hospital in Sao Paulo, Brazil. Patients admitted as inpatients due to laboratory-confirmed COVID-19 between March and August 2020 were consecutively invited for a follow-up in-person visit 6 to 11 months after hospitalization. Ten symptoms of PASC were assessed using standardized scales. Physical activity was assessed by questionnaire and participants were classified according to WHO Guidelines. 614 patients were analyzed (age: 56 ± 13 years; 53% male). Frequency of physical inactivity in patients exhibiting none, at least 1, 1-4, and 5 or more symptoms of PASC was 51%, 62%, 58%, and 71%, respectively. Adjusted models showed that patients with one or more persistent PASC symptoms have greater odds of being physically inactive than those without any persistent symptoms (OR: 1.57 [95% CI 1.04-2.39], P = 0.032). Dyspnea (OR: 2.22 [1.50-3.33], P < 0.001), fatigue (OR: 2.01 [1.40-2.90], P < 0.001), insomnia (OR: 1.69 [1.16-2.49], P = 0.007), post-traumatic stress (OR: 1.53 [1.05-2.23], P = 0.028), and severe muscle/joint pain (OR: 1.53 [95% CI 1.08-2.17], P = 0.011) were associated with greater odds of being physically inactive. This study suggests that PASC is associated with physical inactivity, which itself may be considered as a persistent symptom among COVID-19 survivors. This may help in the early identification of patients who could benefit from additional interventions tailored to combat inactivity (even after treatment of PASC), with potential beneficial impacts on overall morbidity/mortality and health systems worldwide.
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