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Monoclonal gammopathy of thrombotic/thrombocytopenic significance

2023; Elsevier BV; Volume: 141; Issue: 14 Linguagem: Inglês

10.1182/blood.2022018797

1528-0020

Adam J. Kanack, Jordan K. Schaefer, Meera Sridharan, Noah P. Splinter, Mindy Kohlhagen, Bandana Singh, Silvana B. De Lorenzo, Emily Mauch, Maen Hussein, Marwan Shaikh, Shaji Kumar, Renren Wen, Demin Wang, David Murray, Anand Padmanabhan,

Platelet Disorders and Treatments

][5][6][7] Here, we present the case of a patient with recurrent thrombosis and thrombocytopenia, secondary to a persistent anti-PF4/polyanion monoclonal antibody due to an underlying neoplastic condition, which we refer to as monoclonal gammopathy of thrombotic/thrombocytopenic significance (MGTS).The implications of these findings for the investigation of unexplained thrombophilia are discussed.