Produção Nacional
Revisado por pares
Parkinson's Disease‐Cognitive Rating Scale ( PD‐CRS ): Normative Data and Mild Cognitive Impairment Assessment in Brazil
2023; Wiley; Volume: 10; Issue: 3 Linguagem: Inglês
10.1002/mdc3.13657
ISSN2330-1619
AutoresPedro Renato de Paula Brandão, Danilo Assis Pereira, Talyta Grippe, Diógenes Diego de Carvalho Bispo, Fernando Bisinoto Maluf, Márcia Pereira Yunes, Gilberto Nunes Filho, Cândida Helena Lopes Alves, Javier Pagonabarraga, Jaime Kulisevsky, Andressa Mátos Luiz da Costa, Cristiano Franco do Val Serafim, Ana Carolina da Bouza Ferreira, Arthur de Melo Monteiro Bastos, Ana Clara Fernandes Belchior, Beatriz Luna Coutinho de Almeida, Brenda Macedo de Almeida e Castro, Matheus Sampaio Matos, Rodrigo Cardoso de Matos, Gabriel de Almeida Rios, Lorena Oliveira Carneiro, Bianca Christie Costa da Mota, Lucas Ernesto do Rêgo Castro, Vitória Luísa Silveira Rocha, Maria Clotilde Henriques Tavares, Francisco Cardoso,
Tópico(s)Neurobiology of Language and Bilingualism
ResumoAbstract Background The Parkinson's Disease‐Cognitive Rating Scale (PD‐CRS) assesses posterior‐cortical and frontal‐subcortical cognitive functioning and distinguishes mild cognitive impairment in Parkinson's disease (PD‐MCI); however, it was not evaluated in Brazil. Objectives To investigate PD‐CRS's reliability, validity, normative data, and accuracy for PD‐MCI screening in Brazil. Methods The effects of age, education, and sex on PD‐CRS scores were explored. The instrument was tested in 714 individuals (53% female, 21–94 years), with a broad range of education and no neurodegenerative disorder. Trail Making, Consonant Trigrams, Five‐Point, and semantic fluency tests were administered for comparison. A second study enrolled patients with PD and intact cognition (n = 44, 59.75 ± 10.79 years) and with PD‐MCI (n = 25, 65.76 ± 10.33 years) to investigate criterion validity. PD‐CRS subtests were compared with the Cambridge Automated Neuropsychological Battery memory and executive tasks. Results PD‐CRS was unidimensional and reliable (McDonald's ω = 0.83). Using robust multiple regressions, age, and education predicted the total and derived scores in the normative sample. At the 85‐point cutoff, PD‐MCI was detected with 68% sensitivity and 86% specificity (area under the curve = 0.870). PD‐CRS scores strongly correlated with executive and verbal/visual memory tests in both normative and clinical samples. Conclusions This study investigated the applicability of PD‐CRS in the Brazilian context. The scale seems helpful in screening for PD‐MCI, with adequate internal consistency and construct validity. The PD‐CRS variance is influenced by age and educational level, a critical issue for cognitive testing in countries with educational and cultural heterogeneity.
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