Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2
2023; Lippincott Williams & Wilkins; Volume: 147; Issue: 3 Linguagem: Inglês
10.1161/circulationaha.122.061688
ISSN1524-4539
AutoresSha Chen, Qian Wang, Andriana Christodoulou, N Mylonas, Diane Bakker, Rianne Nederlof, Markus W. Hollmann, Nina C. Weber, Ruben Coronel, Vincent Wakker, Vincent M. Christoffels, Ioanna Andreadou, Coert J. Zuurbier,
Tópico(s)Hyperglycemia and glycemic control in critically ill and hospitalized patients
ResumoHomeCirculationVol. 147, No. 3Sodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2 No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextSodium Glucose Cotransporter-2 Inhibitor Empagliflozin Reduces Infarct Size Independently of Sodium Glucose Cotransporter-2 Sha Chen, MD, Qian Wang, MD, Andriana Christodoulou, BSc, Nikolaos Mylonas, BSc, Diane Bakker, BSc, Rianne Nederlof, PhD, Markus W. Hollmann, MD, PhD, Nina C. Weber, PhD, Ruben Coronel, MD, PhD, Vincent Wakker, BSc, Vincent M. Christoffels, PhD, Ioanna Andreadou, PhD and Coert J. Zuurbier, PhD Sha ChenSha Chen Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Qian WangQian Wang Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Andriana ChristodoulouAndriana Christodoulou Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece (A.C., N.M., I.A.). , Nikolaos MylonasNikolaos Mylonas Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece (A.C., N.M., I.A.). , Diane BakkerDiane Bakker Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Rianne NederlofRianne Nederlof Institut für Herz- und Kreislaufphysiologie, Medizinische Fakultät und Universitätsklinikum Düsseldorf, Heinrich-Heine-Universität Düsseldorf, Germany (R.N.). , Markus W. HollmannMarkus W. Hollmann https://orcid.org/0000-0001-8248-0244 Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Nina C. WeberNina C. Weber https://orcid.org/0000-0003-1111-9042 Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Ruben CoronelRuben Coronel Department of Experimental Cardiology (R.C.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Vincent WakkerVincent Wakker https://orcid.org/0000-0002-5490-7447 Department of Medical Biology (V.W., V.M.C.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Vincent M. ChristoffelsVincent M. Christoffels https://orcid.org/0000-0003-4131-2636 Department of Medical Biology (V.W., V.M.C.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. , Ioanna AndreadouIoanna Andreadou Laboratory of Pharmacology, Faculty of Pharmacy, National and Kapodistrian University of Athens, Greece (A.C., N.M., I.A.). and Coert J. ZuurbierCoert J. Zuurbier Correspondence to: Coert J. Zuurbier, PhD, Department of Anesthesiology, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Email E-mail Address: [email protected] https://orcid.org/0000-0001-8361-2448 Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology (S.C., Q.W., D.B., M.W.H.., N.C.W., C.J.Z.), Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands. Originally published17 Jan 2023https://doi.org/10.1161/CIRCULATIONAHA.122.061688Circulation. 2023;147:276–279Footnotes*S. Chen, Q. Wang, and A. Christodoulou contributed equally.†I. Andreadou and C.J. Zuurbier contributed equally.Circulation is available at www.ahajournals.org/journal/circFor Sources of Funding and Disclosures, see page 279.Correspondence to: Coert J. Zuurbier, PhD, Department of Anesthesiology, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. Email c.j.[email protected]nlReferences1. Baartscheer A, Schumacher CA, Wüst RCI, Fiolet JWT, Stienen GJM, Coronel R, Zuurbier CJ. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits.Diabetologia. 2017; 60:568–573. doi: 10.1007/s00125-016-4134-xCrossrefMedlineGoogle Scholar2. Chen S, Coronel R, Hollmann MW, Weber NC, Zuurbier CJ. Direct cardiac effects of SGLT2 inhibitors.Cardiovasc Diabetol. 2022; 21:45. doi: 10.1186/s12933-022-01480-1CrossrefMedlineGoogle Scholar3. Nikolaou PE, Mylonas N, Makridakis M, Makrecka-Kuka M, Iliou A, Zerikiotis S, Efentakis P, Kampoukos S, Kostomitsopoulos N, Vilskerts R, et al. Cardioprotection by selective SGLT2-inhibitors in non-diabetic mouse model of myocardial ischemia/reperfusion injury: a class or a drug effect?Bas Res Cardiol. 2022; 117:27. doi: 10.1007/s00395-022-00934-7CrossrefMedlineGoogle Scholar4. Udell JA, Schuyler Jones W, Petrie MC, Harrington J, Anker SD, Bhatt DL, Hernandez AF, Butler J. Sodium glucose cotransporter-2 inhibition for acute myocardial infarction.J Am Coll Cardiol. 2022; 79:2058–2068. doi: 10.1016/j.jacc.2022.03.353CrossrefMedlineGoogle Scholar5. Paolissa P, Bergamaschi L, Santulli G, Gallinoro E, Gragnano F, Sardu C, MIleva N, Foa A, Armillotta M, Sansonetti A, et al. Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry.Cardiovasc Diabetol. 2022; 21:77. doi: 10.1186/s12933-022-01506-8CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails January 17, 2023Vol 147, Issue 3 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.061688PMID: 36649392 Originally publishedJanuary 17, 2023 Keywordsketonesbody weightsodium-glucose cotransporter 2 inhibitorempagliflozinglucoseinfarct sizeischemia/reperfusionPDF download Advertisement SubjectsBasic Science ResearchIschemiaMyocardial InfarctionPathophysiology
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