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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Synthesis of Bis(3‐indolyl)methanes Mediated by Potassium tert‐ Butoxide

2023; WileyOpen; Volume: 12; Issue: 1 Linguagem: Inglês

10.1002/open.202200265

ISSN

2191-1363

Autores

A. Sofia Santos, Rita Ferro, Nuno Viduedo, Luísa B. Maia, Artur M. S. Silva, M. Manuel B. Marques,

Tópico(s)

Radical Photochemical Reactions

Resumo

The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols.

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