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Transient Inferior ST-Segment Elevation and Ventricular Fibrillation After Cavotricuspid Isthmus Pulsed-Field Ablation

2023; Elsevier BV; Volume: 9; Issue: 5 Linguagem: Inglês

10.1016/j.jacep.2022.11.027

2405-5018

Domenico G. Della Rocca, Alvise Del Monte, Gezim Bala, Luigi Pannone, Erwin Ströker, Cinzia Monaco, Alexandre Almorad, Juan Sieira, Antonio Sorgente, Carlo de Asmundis, Gian‐Battista Chierchia,

Cardiac electrophysiology and arrhythmias

Ultra-low temperature cryoablation (ULTC) using near-critical nitrogen (−196ºC) has been shown to produce durable, contiguous, transmural lesions in ventricles of animal models. This report summarizes acute experience with ULTC in the first-ever 13 patients with recurrent monomorphic ventricular tachycardias (VTs) of both ischemic cardiomyopathy and nonischemic etiologies enrolled in the CryoCure-VT (Cryoablation for Monomorphic Ventricular Tachycardia; NCT04893317) clinical trial. After an average of 9.6 ± 4.6 endocardial ULTC lesions per patient, no clinical ventricular tachycardias were inducible in 91% of patients. Two procedure-related serious adverse events recorded in 2 patients resolved post-procedurally without clinical sequelae. Further investigation of both acute and chronic outcomes is warranted and ongoing.